黏细菌：天然的制药厂

doi:10.13560/j.cnki.biotech.bull.1985.2014.12.007

摘要/Abstract

摘要： 黏细菌及其抗性代谢产物的药用开发已经成为近年来科研工作者研究的热点之一。黏细菌是一类重要的天然产物生产者，它产生的次级代谢产物无论是在化学结构还是生物活性上都具有丰富的多样性。代谢产物的多样性及广谱活性，在开发成药物方面具有巨大的潜力。主要综述了黏细菌独特的细胞行为，产生次级代谢产物的杰出能力，并且阐述了黏细菌药物埃博霉素的研发进展，最后对黏细菌次级代谢产物开发应用潜力进行了展望。

关键词: 黏细菌, 次级代谢产物, 药物研究, 埃博霉素

Abstract: In recent years, drug development of myxobacteria and its resistant metabolic products has become one of the hot topics of researches study. Myxobacteria is an kind of important natural products producer. There is rich diversity in both the chemical structure and biological activity of these secondary metabolites. The diversity and broad-spectrum activity of metabolites have great potential in drug development field. This review describes the unique cell behavior in myxobacteria and its outstanding ability of producing secondary metabolites, and also expounds the progress of epothilone drug development. Finally, we discuss the potential of developing myxobacterial secondary metabolites into new drugs.

Key words: Myxobacteria, Secondary metabolites, Epothiones, Drug discovery

赵婷峰 ,龚国利. 黏细菌：天然的制药厂[J]. 生物技术通报, 2014, 0(12): 40-46.

Zhao Tingfeng, Gong Guoli. Myxobacteria ：Natural Pharmaceutical Factories[J]. Biotechnology Bulletin, 2014, 0(12): 40-46.

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