WRKY转录因子的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2017-0703

摘要/Abstract

摘要： WRKYs是高等植物中最大的转录因子家族（TFs）之一。它具有特殊结构-WRKY结构域,这些结构可使WRKY转录因子拥有不同的转录调控功能。WRKY TFs不仅可以通过调节植物激素信号转导途径来调节它们的应激反应,还可以结合其靶基因启动子中的W-box[TGACC（A / T）],通过激活或抑制下游基因的表达来调节它们的应激反应。此外,WRKY蛋白不仅可以与其他TFs相互作用来调控植物防御反应,而且还可以通过识别和结合本身目标基因中的W-box进行自我调节以调控其对各种压力的防御反应。因此,WRKY TFs不管是在植物响应生物胁迫中,还是非生物胁迫中都具有重要的作用。但是,近年来,关于WRKY TFs在高等植物中的调控作用的研究综述稀少且深度较浅。重点阐述了WRKY TFs的结构特征和分类,在植物生物胁迫和非生物胁迫中发挥的作用,以及通过调节植物激素信号转导途径、MAPK信号级联和自调控来调控各种胁迫,以期为将来WRKY TFs的研究提供理论参考和思路。

关键词: WRKY转录因子, 网络调控, 胁迫

Abstract: WRKYs is one of the largest transcription factor families（TFs）in higher plants. It has a special structure of WRKY domain,which allows WRKY transcription factors to have different transcriptional regulatory functions. WRKY TFs can regulate their stress responses not only by regulating the plant hormone signal transduction pathways,also by activating or inhibiting the expressions of downstream genes while binding to the W-box（TGACC（A/T））in the target gene promoter. In addition,WRKY protein can regulate plant defense responses to various stresses not only by interacting with other TFs,also by self-regulation while identifying and combining the W-box in its own target gene. Therefore,WRKY TFs play important roles in the responses of plants to biological and abiotic stresses. However,the current research on the regulatory roles of WRKY TFs in higher plants is rare and simple in recent years. In order to provide theoretical reference and ideas for future research on WRKY TFs,here we mainly summarized the structural features and classification of WRKY TFs,the roles in plant biological and abiotic stresses,and the regulations to various stresses via hormone signal transduction pathway,MAPK signal cascade and self-regulation.

Key words: WRKY transcription factor, network control, stress

张凡, 尹俊龙, 郭瑛琪, 岳艳玲. WRKY转录因子的研究进展[J]. 生物技术通报, 2018, 34(1): 40-48.

ZHANG Fan, YIN Jun-long, GUO Ying-qi, YUE Yan-ling. Research Advances on WRKY Transcription Factors[J]. Biotechnology Bulletin, 2018, 34(1): 40-48.

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