肠肝轴在动物营养代谢和免疫中的作用

doi:10.13560/j.cnki.biotech.bull.1985.2021-1322

摘要/Abstract

摘要：

肠肝轴是指肠道微生物与肝脏的之间存在的一种双向关系,是肠道微生物对宿主产生影响的重要途径。越来越多的研究表明,肠肝轴在动物营养代谢和机体免疫方面发挥着重要的调节作用。本文从肠肝轴在肠道微生物与宿主互作中发挥的桥梁作用出发,论述了肠肝轴在动物营养代谢和机体免疫中的两种调控机理：内源性大麻素系统和肠道微生物衍生信号。其中,肠道微生物衍生信号包括短链脂肪酸、胆汁酸、胆碱代谢产物、氨基酸类代谢物以及微生物相关分子模式。最后,探讨了肠肝轴理论在畜牧业生产中的应用前景,以期为无抗背景下的动物健康高效养殖提供支持。

关键词: 肠肝轴, 营养免疫, 内源性大麻素系统, 短链脂肪酸, 胆汁酸, 微生物相关分子模式

Abstract:

The gut-liver axis is a bidirectional relationship between intestinal microorganisms and the liver,which is essential for the intestinal microbe to affect the host. Growing studies have shown that the gut-liver axis plays a key regulatory role in animal nutrition metabolism and body immunity. Based on the bridge role of the gut-liver axis in the interaction between intestinal microbe and host,this review discusses two regulatory mechanisms of gut-liver axis in animal nutrition metabolism and body immunity：endocannabinoid system and gut microbiota-derived signals. Gut microbiota-derived signals include short-chain fatty acids,bile acids,choline metabolites,amino acid metabolites,and microbial-related molecular patterns. Finally,the paper discusses application prospect of gut-liver axis theory in animal husbandry production,aiming to provide support for healthy and efficient animal feeding without antibiotics.

Key words: gut-liver axis, nutritional immunity, the endocannabinoid system, short-chain fatty acids, bile acids, microbial-related molecular patterns

蒋贤哲, 张博彦, 罗海玲, 张新盟, 王炳. 肠肝轴在动物营养代谢和免疫中的作用[J]. 生物技术通报, 2022, 38(7): 128-135.

JIANG Xian-zhe, ZHANG Bo-yan, LUO Hai-ling, ZHANG Xin-meng, WANG Bing. Role of Gut-Liver Axis in Animal Nutritional Metabolism and Immunity[J]. Biotechnology Bulletin, 2022, 38(7): 128-135.

图/表 1

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