氧化还原伴侣工程：P450低效问题的解决方案之一

张岩峰, 叶丽丹, 于洪巍

Redox Partner Engineering: A Solution to the Low Catalytic Efficiency of P450s

ZHANG Yan-feng, YE Li-dan, YU Hong-wei

图2 经典RPs支持的部分氧化还原反应 a：孕酮的16α-羟基化；b: 11-脱氧皮质酮的11β-羟基化；c：苯甲硫醚的硫氧化；d：磺酰脲类药物格列美脲的3-环己基羟基化；e：十六醛的脱甲酰化

Fig. 2 Examples of partial redox reactions supported by classical RPs a: 16α-hydroxylation of progesterone; b: 11β-hydroxylation of 11-deoxycorticosterone; c: sulfur oxidation of thioanisole; d: 3-cyclohexyl-hydroxylation of the sulfonylurea drug glimepiride; e: deformylation of n-hexadecanal