[1]Seal BS, Lillehoj HS, Donovan DM, et al. Alternatives to antibiotics:a symposium on the challenges and solutions for animal production[C]//Animal health research reviews. Conference of Research Wor-kers in Animal Diseases, 2013:1-10. [2]Kaufmann BB, Hung DT. The fast track to multidrug resistance[J]. Molecular Cell, 2010, 37(3):297-298. [3]王兴顺, 耿艺介, 李文楚, 等. 抗菌肽抗菌机制及其应用研究进展[J]. 微生物学免疫学进展, 2012, 40(4):70-76. [4]Li Y, Qu H, Xiang Q, et al. Overview on the recent study of antimicrobial peptides:origins, functions, relative mechanisms and application[J]. Peptides, 2012, 37(2):207-215. [5]Pigeon C, Ilyin G, Courselaud B, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload[J]. Journal of Biological Chemistry, 2001, 276(11):7811-7819. [6]Chen JY, Lin WJ, Lin TL. A fish antimicrobial peptide, tilapia hepcidin TH2-3, shows potent antitumor activity against human fibrosarcoma cells[J]. Peptides, 2009, 30(9):1636-1642. [7]Zasloff M. Antimicrobial peptides of multicellular organisms[J]. Nature, 2002, 415(6870):389-395. [8]Jenssen H, Hamill P, Hancock REW. Peptide antimicrobial agents[J]. Clin Microbiol Rev, 2006, 19(3):491-511. [9] Riley MA, Wertz JE. Bacteriocins:evolution, ecology, and applica-tion[J]. Ann Revi Microbiol, 2002, 56(1):117-137. [10] Hajji M, Jellouli K, Hmidet N, et al. A highly thermostable antimicrobial peptide from Aspergillus clavatus ES1:biochemical and molecular characterization[J]. Journal of Industrial Microbiology & Biotechnology, 2010, 37(8):805-813. [11]Stec B. Plant thionins-the structural perspective[J]. Cellular and Molecular Life Sciences CMLS, 2006, 63(12):1370-1385. [12] Wang KJ, Huang WS, Yang M, et al. A male-specific expression gene, encodes a novel anionic antimicrobial peptide, scygonadin, in Scylla serrata[J]. Mol Immunol, 2007, 44(8):1961-1968. [13]黄文树. 锯缘青蟹一种新的阴离子抗菌肽scygonadin 及其基因的分离与鉴定[D]. 厦门:厦门大学, 2006. [14]Huang WS, Wang KJ, Yang M, et al. Purification and part characterization of a novel antibacterial protein Scygonadin, isolated from the seminal plasma of mud crab, Scylla serrata(Forsk?l, 1775)[J]. J Exp Mar Biol and Ecology, 2006, 339(1):37-42. [15] 范丹青. 拟穴青蟹(Scylla paramamosain)Histone 2A 的基因克隆, 表达及其合成肽 Sphistin 的抗菌特性与抗菌机理研究[D]. 厦门:厦门大学, 2011. [16]Wang KJ, Cai JJ, Cai L, et al. Cloning and expression of a hepcidin gene from a marine fish(Pseudosciaena crocea)and the antimicrobial activity of its synthetic peptide[J]. Peptides, 2009, 30(4):638-646. [17]王克坚, 周红铃, 杨明. 海水养殖鲈鱼分离出一种hepcidin 抗菌肽新基因[J]. 厦门大学学报:自然科学版, 2004, 43(3):286-287. [18]Ren HL, Wang KJ, Zhou HL, et al. Cloning and organisation analy-sis of a hepcidin-like gene and cDNA from Japan sea bass, Lateola-brax japonicus[J]. Fish Shellfish Immunol, 2006, 21:221-227. [19]陈君慧, 王克坚, 周红玲, 等. 花鲈肝脏 hepcidin 相关 cDNA Hepc2 的克隆及序列分析[J]. 中国生态农业学报, 2007, 15(3):129-132. [20]杨明, 王克坚, 周红玲. 我国海水养殖真鲷分离出 hepcidin 抗菌肽新基因[J]. 高技术通讯, 2004, 14:323-328. [21]杨明, 王克坚, 曲海东, 等. 真鲷鳃组织 cDNA 文库的构建与 hepcidin 抗菌肽基因序列的扩增[J]. 水产学报, 2006, 30(5):627-632. [22]Yang M, Wang KJ, Chen JH, et al. Genomic organization and tissue-specific expression analysis of hepcidin-like genes from black porgy(Acanthopagrus schlegelii)[J]. Fish & Shellfish Immunology, 2007, 23(5):1060-1071. [23]蔡晶晶, 杨明, 蔡灵, 等. 黑鲷抗菌肽 hepcidin 在毕赤酵母中的表达及其抗菌活性[J]. 厦门大学学报:自然科学版, 2009, 48(5):738-743. [24]Yang M, Chen B, Cai JJ, et al. Molecular characterization of hepcidin AS-hepc2 and AS-hepc6 in black porgy(Acanthopagrus schlegelii):expression pattern responded to bacterial challenge and in vitro antimicrobial activity[J]. Comp Biochem Physiol B:Biochem Mol Biol, 2011, 158(2):155-163. [25] Ganz T. Defensins:antimicrobial peptides of innate immunity[J]. Nat Rev Immunol, 2003, 3(9):710-720. [26] Zanetti M. Cathelicidins, multifunctional peptides of the innate immunity[J]. J Leukoc Biol, 2004, 75(1):39-48. [27] Zasloff M. Magainins, a class of antimicrobial peptides from Xenopus skin:isolation, characterization of two active forms, and partial cDNA sequence of a precursor[J]. Proceedings of the National Academy of Sciences, 1987, 84(15):5449-5453. [28]Steiner H, Hultmark D, Engstr?m ?, et al. Sequence and specificity of two antibacterial proteins involved in insect immunity[J]. Nature, 1981, 292:246-248. [29]Scudiero O, Galdiero S, Nigro E, et al. Chimeric beta-defensin analogs, including the novel 3NI analog, display salt-resistant antimicrobial activity and lack toxicity in human epithelial cell lines[J]. Antimicrob Agents Chemother, 2013, 57:1701-1708. [30]Landon C, Thouzeau C, Labbé H, et al. Solution structure of spheniscin, a β-defensin from the penguin stomach[J]. Journal of Biological Chemistry, 2004, 279(29):30433-30439. [31]Kuhn-Nentwig L, Müller J, Schaller J, et al. Cupiennin 1, a new family of highly basic antimicrobial peptides in the venom of the spider Cupiennius salei(Ctenidae)[J]. Journal of Biological Chemistry, 2002, 277(13):11208-11216. [32]Peng H, Yang M, Huang WS, et al. Soluble expression and purification of a crab antimicrobial peptide scygonadin in different expression plasmids and analysis of its antimicrobial activity[J]. Protein Expression and Purification, 2010, 70(1):109-115. [33]Yoe SM, Kang CS, Han SS, et al. Characterization and cDNA cloning of hinnavin II, a cecropin family antibacterial peptide from the cabbage butterfly, Artogeia rapae[J]. Comparative Biochem Physiol B:Biochem Mol Biol, 2006, 144(2):199-205. [34]Ye J, Zhao H, Wang H, et al. A defensin antimicrobial peptide from the venoms of Nasonia vitripennis[J]. Toxicon, 2010, 56(1):101-106. [35] Baek JH, Lee SH. Isolation and molecular cloning of venom peptides from Orancistrocerus drewseni(Hymenoptera:Eumenidae)[J]. Toxicon, 2010, 55(4):711-718. [36]Dang XL, Tian JH, Yang WY, et al. Bactrocerin-1:A novel inducible antimicrobial peptide from pupae of oriental fruit fly Bactrocera dorsalis Hendel[J]. Archives of Insect Biochemistry and Physiology, 2009, 71(3):117-129. [37]Danesi R, Senesi S, Wout JW, et al. Antimicrobial peptides:therapeutic potential for the treatment of Candida infections[J]. Expert Opinion on Investigational Drugs, 2002, 11(2):309-318. [38]Zhang K, Lu Q, Zhang Q, et al. Regulation of activities of NK cells and CD4 expression in T cells by human HNP-1, -2, and-3[J]. Biochem Biophys Res Commun, 2004, 323(2):437-444. [39]Salvatore M, García-Sastre A, Ruchala P, et al. β-defensin inhibits influenza virus replication by cell-mediated mechanism(s)[J]. Journal of Infectious Diseases, 2007, 196(6):835-843. [40]Ryan LK, Dai J, Yin Z, et al. Modulation of human beta-defensin-1(hbd-1)in plasmacytoid dendritic cells(pdc), monocytes, and epithelial cells by influenza virus, herpes simplex virus, and sendai virus and its possible role in innate immunity[J]. J Leukoc Biol, 2011, 90:343-356. [41]Peng H, Liu HP, Chen B, et al. Optimized production of scygonadin in Pichia pastoris and analysis of its antimicrobial and antiviral activities[J]. Protein Expr Purif, 2012, 82(1):37-44. [42]Huang CM, Chen HC, Zierdt CH. Magainin analogs effective against pathogenic protozoa[J]. Antimicrob Agents Chemother, 1990, 34(9):1824-1826. [43] McGwire BS, Olson CL, Tack BF, et al. Killing of African trypanos-omes by antimicrobial peptides[J]. J Infect Dis, 2003, 188:146-152. [44] Haines LR, Thomas JM, Jackson AM, et al. Killing of trypanosom-atid parasites by a modified bovine host defense peptide, BMAP-18[J]. PLoS Neglected Tropical Diseases, 2009, 3(2):e373. [45] Jenssen H, Hamill P, Hancock REW. Peptide antimicrobial agents[J]. Clinical Microbiology Reviews, 2006, 19(3):491-511. [46] Cai L, Cai JJ, Liu HP, et al. Recombinant medaka(Oryzias melas-tigmus)pro-hepcidin:multifunctional characterization[J]. Comp Biochem Physiol B Biochem Mol Biol, 2012, 161:140-147. [47]Gutsmann T, Hagge SO, Larrick JW, et al. Interaction of CAP18-derived peptides with membranes made from endotoxins or phospholipids[J]. Biophys J, 2001, 80(6):2935-2945. [48]Chen Y, Xu X, Hong S, et al. RGD-Tachyplesin inhibits tumor growth[J]. Cancer Research, 2001, 61(6):2434-2438. [49]Charp PA, Rice WG, Raynor RL, et al. Inhibition of protein kinase C by defensins, antibiotic peptides from human neutrophils[J]. Biochemical Pharmacology, 1988, 37(5):951-956. [50]Zhu QZ, Hu J, Mulay S, et al. Isolation and structure of corticostatin peptides from rabbit fetal and adult lung[J]. Proceedings of the National Academy of Sciences, 1988, 85(2):592-596. [51]陈香, 谯仕彦, 李波, 等. 添加天蚕素抗菌肽对断奶仔猪生长性能的影响[J]. 中国饲料, 2011(12):25-26. [52]Choi SC, Ingale SL, Kim JS, et al. Effects of dietary supplementation with an antimicrobial peptide-P5 on growth performance, nutrient retention, excreta and intestinal microflora and intestinal morphology of broilers[J]. Animal Feed Science and Technology, 2013, 185(1):78-84. [53]马倩, 赵衍铜, 柏明娜, 等. 抗菌肽对芦花鸡生产性能和血清生化指标的影响[J]. 饲料研究, 2012(3):27-29. [54]Wu S, Zhang F, Huang Z, et al. Effects of the antimicrobial peptide cecropin AD on performance and intestinal health in weaned piglets challenged with Escherichia coli[J]. Peptides, 2012, 35(2):225-230. [55]van der Marel M, Adamek M, Gonzalez SF, et al. Molecular cloning and expression of two β-defensin and two mucin genes in common carp(Cyprinus carpio)and their up-regulation after β-glucan feeding[J]. Fish Shellfish Immunol, 2012, 32(3):494-501. [56]陈红羽, 谯仕彦. 日粮中添加抗菌肽 cecropin AD 对肉鸡大肠杆菌攻毒条件下肠道菌群和白介素-6 水平变代研究[J]. 饲料与畜牧:新饲料, 2012(5):51-52. [57] 马卫明, 佘锐萍, 胡艳欣, 等. 猪小肠抗菌肽对雏鸡的促生长作用及其机理初探[J]. 中国农业科学, 2006, 39:1723-1728. [58]黄自然, 黄国庆, 黄水彤. 新型饲料添加剂抗菌肽饲养肉鸡的效果[J]. 广东蚕业, 2006, 40(1):30-34. [59]王克坚. 海洋鱼类和青蟹抗菌肽 hepcidin 和 scygonadin 的研究[J]. 厦门大学学报:自然科学版, 2011, 50:418-424. [60] Habets MG, Brockhurst MA. Therapeutic antimicrobial peptides may compromise natural immunity[J]. Biol Lett, 2012, 8:416-418. |