布尼亚病毒基因重排机制研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2018-0706

生物技术通报 ›› 2019, Vol. 35 ›› Issue (2): 171-175.doi: 10.13560/j.cnki.biotech.bull.1985.2018-0706

布尼亚病毒基因重排机制研究进展

石坤, 林祥梅, 吕继洲, 邓俊花, 吴绍强

中国检验检疫科学研究院动物检疫研究所,北京 100176

收稿日期:2018-08-09 出版日期:2019-02-26 发布日期:2019-03-07
作者简介:石坤,女,硕士,研究方向：动物检疫;E-mail：18910870076@163.com
基金资助:
“十三五”国家重点研发计划项目（2016YFD0501100）

Research Progress on Rearrangement Mechanism of Bunyaviruses

SHI Kun, LIN Xiang-mei, LÜ Ji-zhou, DENG Jun-hua, WU Shao-qiang

Institute of Animal Quarantine,Chinese Academy of Inspection and Quarantine,Beijing 100176

Received:2018-08-09 Published:2019-02-26 Online:2019-03-07

摘要/Abstract

摘要： 近年来,发热伴血小板减少综合征（俗称“蜱咬病”）、施马伦贝格病等的发生引起人类对布尼亚病毒的广泛关注。布尼亚病毒是一类传染性强、致死率高的负链RNA病毒。由于其基因组的分段性质,使它的病毒成员之间易发生基因重排,产生致病力增强和宿主范围增加的新病毒,对人类公共卫生构成了重大威胁。从自然界中的布尼亚病毒重排现象、布尼亚病毒的基因重排机理以及基因重排的潜在致病危害等方面对相关研究进行综述,并对下一步的重排机制研究及疫苗研究提出展望,旨为该病的预防与控制提供理论依据。

关键词: 布尼亚病毒, 基因重排, 分子机理

Abstract: In recent years,emerging diseases such as severe fever with throm-bocytopenia syndrome（commonly known as “tick biting disease”）and Schmallenberg disease have caused widespread attentions to Bunyavirus. Bunyavirus is a type of negative-strand RNA virus with high infectivity and high mortality. Due to the fragmented nature of its genome,it is prone to gene rearrangement among its members,resulting in new viruses with increased virulence and increased host range,thus posing a major threat to human health. This article reviews the recent studies on the rearranged phenomena,molecular mechanism and the potential pathogenic hazards of Bunyaviruses rearrangement. Keeping research on the Bunyavirus rearrangement mechanism and the vaccine development is prospected,aiming at providing theoretical basis for the prevention and control of this disease.

Key words: Bunyavirus, gene rearrangement, molecular mechanism.

石坤, 林祥梅, 吕继洲, 邓俊花, 吴绍强. 布尼亚病毒基因重排机制研究进展[J]. 生物技术通报, 2019, 35(2): 171-175.

SHI Kun, LIN Xiang-mei, LÜ Ji-zhou, DENG Jun-hua, WU Shao-qiang. Research Progress on Rearrangement Mechanism of Bunyaviruses[J]. Biotechnology Bulletin, 2019, 35(2): 171-175.

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布尼亚病毒基因重排机制研究进展

Research Progress on Rearrangement Mechanism of Bunyaviruses

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