Rho 鸟嘌呤核苷酸交换因子家族及其在疾病发生中的作用

生物技术通报 ›› 2014, Vol. 0 ›› Issue (1): 63-67.

Rho 鸟嘌呤核苷酸交换因子家族及其在疾病发生中的作用

刘明涛¹,杨军²,王志钢¹

1. 内蒙古大学生命科学学院，呼和浩特 010021; 2. 呼和浩特市环境科学研究所，呼和浩特 010030

收稿日期:2013-08-13 出版日期:2014-01-23 发布日期:2014-01-23
作者简介:刘明涛，男，硕士研究生，研究方向: 基因工程；E-mail: uulmt999@sina.com
基金资助:
国家自然基金项目(31160469)，内蒙古自然基金项目(2011MS0521)

RhoGEF Family and the Role in Occurrence and Development of Diseases

Liu Mingtao¹, Yang Jun², Wang Zhigang¹

1. College of Life Science，Inner Mongolia University，Hohhot 010021;
2. Hohhot Institute of Enviromental Sciences ，Hohhot 010030

Received:2013-08-13 Published:2014-01-23 Online:2014-01-23

摘要/Abstract

摘要： Rho GTP 酶(Rho GTPase) 家族在真核生物细胞中参与细胞骨架调节、基因转录、膜泡运输等过程，扮演着分子#br#开关的角色。Rho 型鸟嘌呤核苷酸交换因子(RhoGEF) 是调节Rho GTPase 活性的关键因子，在Rho GTPase 信号调节、组织器官#br#的生长发育及免疫应答中起着至关重要的作用。RhoGEF 与肿瘤、发育及神经类疾病、病原微生物感染等也有密切关系，对其功能#br#的深入了解有助于人们认识某些生理和病理现象的发生机制。

关键词: Rho GTPase, 鸟嘌呤核苷酸交换因子(GEF), 疾病发生

Abstract: Rho GTPases family plays a role of molecular switch in many cellular processes, including cytoskeletal dynamics, vesicle trafficking and gene transcription. Guanine nucleotide exchange factors(RhoGEFs)are the key regulator of activity for Rho GTPases. RhoGEFs can regulate signal transduction of Rho GTPases, development of tissues or organs and immune response. RhoGEFs are associated with cancer,development or neural system related diseases and pathogen infection, understanding of its function will help us to verify the mechanisms of some physiological and pathological process.

Key words: Rho, GTPase, Guanine nucleotide exchange factors(GEFs), Disease occurrence

刘明涛,杨军,王志钢. Rho 鸟嘌呤核苷酸交换因子家族及其在疾病发生中的作用[J]. 生物技术通报, 2014, 0(1): 63-67.

Liu Mingtao, Yang Jun, Wang Zhigang. RhoGEF Family and the Role in Occurrence and Development of Diseases[J]. Biotechnology Bulletin, 2014, 0(1): 63-67.

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