EPSP合酶的研究进展

摘要/Abstract

摘要： 5-烯醇式丙酮酰莽草酸-3-磷酸合酶（5-Enolpyruvylshikimate-3-phosphate synthase，EPSP合酶）是莽草酸途径中的第六位酶，参与合成芳香族氨基酸以及部分次生代谢的产物，同时EPSP合酶不仅是除草剂草甘膦、抗菌素、抗寄生虫药物的作用靶酶，而且也是促进生物体内莽草酸积累的重要调控位点。近年来，随着分子生物学技术的快速发展和对EPSP合酶的深入研究，EPSP合酶基因在耐草甘膦转基因作物、医药卫生等方面被广泛应用。对EPSP合酶的研究进展进行综述及展望。

关键词: 莽草酸途径, EPSP合酶, 莽草酸积累, 耐草甘膦

Abstract: 5-Enolpyruvylshikimate-3-phosphate synthase（EPSP synthase for short）, is the sixth enzyme of shikimic acid pathway and participates in the synthesis of aromatic amino acids and some of secondary metabolites. Meanwhile, EPSP synthase are not only targets of the herbicide（glyphosate）, antibiotics, anti-parasitic drugs, but also is important regulatory site of promoting the accumulation of shikimic acid in the organism. In recent years, with the rapid development of molecular biology technology and the in-depth study of EPSP synthase, EPSP synthase genes have been widely used in resistance to glyphosate genetically modified crops, medicine and health, etc. The research progress of EPSP synthase were reviewed and prospects in this paper.

Key words: Shikimate pathway, EPSP synthase, Shikimic acid accumulation, Resistance to glyphosate

徐杰, 蒋世云, 傅凤鸣, 耿鹏飞, 黄凯. EPSP合酶的研究进展[J]. 生物技术通报, 2014, 0(6): 40-50.

Xu Jie, Jiang Shiyun, Fu Fengming, Geng Pengfei, Huang Kai. The Research Progress of EPSP Synthase[J]. Biotechnology Bulletin, 2014, 0(6): 40-50.

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