对虾白斑综合症病毒极早期基因的研究进展

摘要/Abstract

摘要： 对虾白斑综合症病毒（white spot syndrome virus，WSSV）是危害对虾养殖业的主要病原之一。WSSV在侵染宿主细胞的过程中，极早期基因（immediate-early gene）对病毒复制增殖起着非常重要的作用。在这个过程中，一方面极早期基因编码的蛋白通过与细胞调控因子相互作用，调节细胞信号通路，为病毒的增殖提供更合适的环境；另一方面，极早期蛋白直接调控病毒基因的转录和表达。综述列举了WSSV的21个极早期基因，并将重点介绍其中5个研究比较深入的基因：ie1、wsv051、wsv083、wsv249和wsv403。

关键词: WSSV极早期基因, ie1, wsv051, wsv083, wsv249, wsv403

Abstract: White spot syndrome virus is one of the main pathogens which causes great damage to the shrimp aquaculture. During the infection, WSSV immediate-early genes（IE genes）utilize the host cell transcription regulators to increase their own transcription. Regulatory proteins encoded by IE genes are critical for the virus life cycle. The IE proteins may either regulate the expression of viral genes, or interact with regulators in the host cells to create a proper environment for viral replication. Here we reviewed the recent progress in WSSV IE gene research and especially focused on five most-studied WSSV immediate-early genes：ie1, wsv051, wsv083, wsv249 and wsv403. The function of IE proteins and the transcription regulation of their genes were discussed.

Key words: WSSV immediate-early genes, ie1, wsv051, wsv083, wsv249 wsv403

冉晓卓, 李钫. 对虾白斑综合症病毒极早期基因的研究进展[J]. 生物技术通报, 2014, 0(8): 52-58.

Ran Xiaozhuo, Li Fang. A Review of Development in WSSV Immediate-early Gene Research[J]. Biotechnology Bulletin, 2014, 0(8): 52-58.

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