海洋无脊椎动物甲状腺激素信号通路的研究进展

摘要/Abstract

摘要： 在脊椎动物中,甲状腺激素信号通路是调控生长、发育和机体能量代谢必不可少的信号通路之一,并且参与了两栖类和鱼类的变态反应。近来,越来越多的证据表明,在海洋无脊椎动物中存在内源性的甲状腺激素、甲状腺激素受体等信号通路的成员分子,而且这些分子参与了海洋无脊椎动物的发育和变态过程。这表明在海洋无脊椎动物中存在与脊椎动物类似的甲状腺激素信号通路。综述了海洋无脊椎动物中甲状腺激素信号通路的相关研究进展,旨在为研究甲状腺激素在海洋无脊椎动物的生物学功能及其作用机制提供基础资料。

关键词: 海洋无脊椎动物, 甲状腺激素, 甲状腺过氧化物酶, 甲腺原氨酸脱碘酶, 甲状腺激素受体

Abstract: In vertebrates, thyroid hormones（THs）signaling pathway is essential for the animal’s growth, development and energy metabolism. In addition, it also involved in metamorphosis process of the amphibian and fish. In recent, increasing evidence supports the existence of signal molecules of THs signaling pathway in marine invertebrates, such as endogenous THs and thyroid hormone receptors（TRs）and so on. And, these signal molecules involved in the development and metamorphosis process of marine invertebrates. It suggests that the THs signaling pathway exists in marine invertebrates, and it shows similarity with the vertebrates. This paper aims at a summary of thyroid hormone signaling pathway and its research advance in marine invertebrate, so as to provide basic data for the study of biological function of THs signaling pathway in marine invertebrates.

Key words: Marine invertebrates, Thyroid hormones, Thyroid peroxidase, Iodothyronine deiodinases, Thyroid hormone receptors

徐建波, 张丽莉, 王艺磊, 王国栋. 海洋无脊椎动物甲状腺激素信号通路的研究进展[J]. 生物技术通报, 2014, 0(10): 23-32.

Xu Jianbo, Zhang Lili, Wang Yilei, Wang Guodong. Thyroid Hormone Signaling Pathway and Its Research Advance in Marine Invertebrate[J]. Biotechnology Bulletin, 2014, 0(10): 23-32.

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