植物内质网胁迫应答研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2016.10.005

摘要/Abstract

摘要： 内质网是所有分泌蛋白和大部分膜蛋白合成和折叠的场所。当植物处于逆境时,错误折叠和未折叠蛋白会大量积累在内质网,导致内质网胁迫,为了缓解胁迫,细胞会启动保守的未折叠蛋白应答途径去帮助蛋白折叠,或将错误折叠蛋白降解。内质网胁迫应答在植物发育、抗逆、抗病等过程中发挥了重要的作用。总结了近年来内质网胁迫在植物中的相关报道,对膜结合转录因子和内质网胁迫之间的关系进行了阐述,并提出在研究内质网胁迫途径中未解决的问题,以期为进一步理解内质网胁迫和抗逆的关系提供一些参考。

关键词: 蛋白折叠, 内质网胁迫, 未折叠蛋白应答, 膜结合转录因子

Abstract: Endoplasmic reticulum（ER）is an important organelle in eukaryotic cells where all the secreted proteins and most of the membrane protein are synthesized. When plants are exposed to various stresses,such as heat and high salinity,unfolded and misfolded proteins are accumulated in the endoplasmic reticulum（ER）,which triggers a well-conserved pathway called the unfolded protein response （UPR）to mitigate the ER stress and promote cell survival. In this review,we summarized the current advances in the understanding of the membrane-associated transcription factors and ER stress responses in plants. We also discussed future directions in this field and the potential uses of the ER stress signaling pathway for improving the stress tolerance of plants.

Key words: protein folding, ER stress, unfolded protein response, membrane-associated transcription factor

杨正婷, 刘建祥. 植物内质网胁迫应答研究进展[J]. 生物技术通报, 2016, 32(10): 84-96.

YANG Zheng-ting, LIU Jian-xiang. Endoplasmic Reticulum Stress Response in Plants[J]. Biotechnology Bulletin, 2016, 32(10): 84-96.

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