免疫细胞在棕色脂肪产热及白色脂肪棕色化过程中的功能研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2019-0542

摘要/Abstract

摘要： 肥胖已经成为威胁人类健康的全球性问题,棕色脂肪（Brown adipose tissue,BAT）及米色脂肪因其能够通过产热作用增加能量消耗这一特性,已成为一种备受关注的潜在肥胖治疗方法。近年来的研究发现M2型巨噬细胞（Alternatively activated macrophages,M2 type）能够促进BAT产热和白色脂肪（White adipose tissue,WAT）的棕色化（即米色脂肪的形成过程）,但随后的一些研究却得到了相反的结论。到目前为止,M2型巨噬细胞是否参与促进WAT的棕色化过程仍是一个备受争议的话题。主要对M2型巨噬细胞、II型固有淋巴细胞（Type 2 Innate Lymphoid Cells,ILC2s）和嗜酸性粒细胞（Eosinophils）对BAT产热和WAT的棕色化的促进作用,以及M2型巨噬细胞不参与/抑制WAT棕色化这两个方面的研究状况做一综述。

关键词: M2型巨噬细胞, II型固有淋巴细胞, 嗜酸性粒细胞, 棕色脂肪和米色脂肪, 白色脂肪棕色化

Abstract: Obesity has become a global prevalent disease that threats human health. Brown adipose tissue（BAT）and beige adipocytes have attracted considerable attention as a novel therapeutic intervention in the treatment of obesity,due to the features of increasing energy consumption via thermogenesis. M2 macrophages（alternatively activated macrophages,M2 type）was recently found to have an unexpected involvement in promoting the thermogenic activity of BAT and browning of white adipose tissue（WAT）,i.e.,the processing of beige adipocyte biogenesis,but later researches had come to the opposite conclusion. Whether M2 macrophages involved in browning of WAT is still controversial. Herein,we review the promoting effect of M2 macrophages,type II innate lymphoid cells and eosinophils on BAT thermogenesis and browning of WAT. Also we summarize the studies about the M2 macrophages having no effect and inhibiting effect on browning of white adipose tissue.

Key words: M2 macrophages, type II innate lymphoid cells, eosinophils, brown and brite adipocytes, browning of white adipose tissue

孙文阳, 林建春, 滚双宝, 王金勇. 免疫细胞在棕色脂肪产热及白色脂肪棕色化过程中的功能研究进展[J]. 生物技术通报, 2020, 36(1): 175-181.

SUN Wen-yang, LIN Jian-chun, GUN Shuang-bao, WANG Jin-yong. Progress of Immunocyte in the Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue[J]. Biotechnology Bulletin, 2020, 36(1): 175-181.

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