乙酰化修饰在植物病原物致病过程中的作用

doi:10.13560/j.cnki.biotech.bull.1985.2023-1179

摘要/Abstract

摘要：

赖氨酸乙酰化修饰作为生物体内一种保守的蛋白翻译后修饰，参与多种生物学过程。大量的医学和植物病理学研究指出，乙酰化修饰在动物疾病和植物病害发生过程中发挥重要的调控作用。本文根据前人的研究进展，就乙酰化修饰参与植物病原物的致病过程，主要包括乙酰化修饰在调控病原物的生长发育和致病力，寄主植物的抗性以及病原物与寄主植物之间的互作等三方面内容阐述乙酰化修饰在植物病原物中的作用，旨在了解乙酰化修饰在病原物致病过程中发挥的作用，以期为病原物的防控提供新思路和新理论。

关键词: 植物病原物, 乙酰化修饰, 致病过程, 防御反应

Abstract:

Lysine acetylation, as a conservative post-translational modification, participates in a variety of biological processes. Numerous medical and plant pathological studies have revealed that acetylation plays an important regulatory role in the development of animal and plant diseases. Based on previous research progress, this article elaborates on the role of acetylation in plant pathogens from three perspectives involved in the pathogenesis of plant pathogens: Regulation of pathogen growth and pathogenicity, host plant resistance, and pathogen-host plant interaction. The aim is to understand the role of acetylation in the pathogenic process and to provide new ideas and theoretical support for the prevention and control of the pathogens.

Key words: plant pathogens, acetylation, pathogenic process, defensive response

王立超, 李欢, 盛若成, 李敏, 陈凤毛. 乙酰化修饰在植物病原物致病过程中的作用[J]. 生物技术通报, 2024, 40(5): 1-12.

WANG Li-chao, LI Huan, SHENG Ruo-cheng, LI Min, CHEN Feng-mao. Role of Acetylation in the Pathogenic Process of Plant Pathogens[J]. Biotechnology Bulletin, 2024, 40(5): 1-12.

图/表 4

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病原菌 Species	菌株 Strain	乙酰化位点 Acetylated sites	乙酰化蛋白 Acetylated proteins	与致病力相关 Relevant to pathogenicity	年份 Year	参考文献 Reference
禾谷镰刀菌 F. graminearum	PH-1	577	364	Yes	2016	[8]
	PH-1	2 400	1 642	Yes	2019	[9]
	Fggcn5 mutant	2 352	1 599	Yes	2019	[9]
稻瘟菌 M. oryzae	Wild-type	1 501	660	Yes	2018	[10]
	GCN5 overexpression	1 509	666	Yes	2018	[10]
	Vegetative hyphae	2 720	1 269	Yes	2017	[11]
大豆疫霉P. sojae	Wild-type	2 197	1 150	Yes	2016	[12]
灰葡萄孢B. cinerea	B05.10	1 582	954	Yes	2016	[14]
梨火疫病菌 E. amylovora	Ea273	61	46	Yes	2013	[15]
梨火疫病菌 E. amylovora	Ea1189	100	67	Yes	2013	[15]
板栗疫病菌 C. parasitica	EP155	550	260	/	2023	[16]
板栗疫病菌 C. parasitica	EP155/CHV1-EP713	554	250	/	2023	[16]
核桃溃疡病原菌B. nigrifluens	LMG 2694	1 866	737	Yes	2020	[17]

病原菌 Species	菌株 Strain	乙酰化位点 Acetylated sites	乙酰化蛋白 Acetylated proteins	与致病力相关 Relevant to pathogenicity	年份 Year	参考文献 Reference
禾谷镰刀菌 F. graminearum	PH-1	577	364	Yes	2016	[8]
	PH-1	2 400	1 642	Yes	2019	[9]
	Fggcn5 mutant	2 352	1 599	Yes	2019	[9]
稻瘟菌 M. oryzae	Wild-type	1 501	660	Yes	2018	[10]
	GCN5 overexpression	1 509	666	Yes	2018	[10]
	Vegetative hyphae	2 720	1 269	Yes	2017	[11]
大豆疫霉P. sojae	Wild-type	2 197	1 150	Yes	2016	[12]
灰葡萄孢B. cinerea	B05.10	1 582	954	Yes	2016	[14]
梨火疫病菌 E. amylovora	Ea273	61	46	Yes	2013	[15]
梨火疫病菌 E. amylovora	Ea1189	100	67	Yes	2013	[15]
板栗疫病菌 C. parasitica	EP155	550	260	/	2023	[16]
板栗疫病菌 C. parasitica	EP155/CHV1-EP713	554	250	/	2023	[16]
核桃溃疡病原菌B. nigrifluens	LMG 2694	1 866	737	Yes	2020	[17]

病原物 Pathogen	去乙酰化酶种类 Type of deacetylase	菌丝生长 Mycelial growth	菌落形态 Colony morphology	产孢量 Conidial production	耐受性 Tolerance	致病力 Pathogenicity	参考文献 Reference
稻瘟菌 M. oryzae	MoRpd3	N	/	D	/	D	[21]
	MoHos2	D	N	D	/	D	[22]
	MoHda1	D	N	D	/	D	[23]
链格孢 A. alternata	AaRap3	D	Y	D	N	D	[28]
	AaHos2	D	N	D	D	D	[28]
	AaHos3	N	N	N	N	N	[28]
	AaHda1	N	N	N	N	N	[28]
	AaHst2	N	N	N	N	D	[28]
	AaSirt2	N	N	N	N	N	[28]
灰葡萄孢B. cinerea	BcRpd3	D	/	N	D	D	[29]
果生炭疽菌C. fructicola	Cfsnt2	D	Y	D	D	D	[32]

病原物 Pathogen	去乙酰化酶种类 Type of deacetylase	菌丝生长 Mycelial growth	菌落形态 Colony morphology	产孢量 Conidial production	耐受性 Tolerance	致病力 Pathogenicity	参考文献 Reference
稻瘟菌 M. oryzae	MoRpd3	N	/	D	/	D	[21]
	MoHos2	D	N	D	/	D	[22]
	MoHda1	D	N	D	/	D	[23]
链格孢 A. alternata	AaRap3	D	Y	D	N	D	[28]
	AaHos2	D	N	D	D	D	[28]
	AaHos3	N	N	N	N	N	[28]
	AaHda1	N	N	N	N	N	[28]
	AaHst2	N	N	N	N	D	[28]
	AaSirt2	N	N	N	N	N	[28]
灰葡萄孢B. cinerea	BcRpd3	D	/	N	D	D	[29]
果生炭疽菌C. fructicola	Cfsnt2	D	Y	D	D	D	[32]

病原物 Pathogen	乙酰转移酶种类 Types of acetyltransferase	菌丝生长 Mycelial growth	菌落形态 Colony morphology	产孢量 Conidial production	耐受性 Tolerance	致病力 Pathogenicity	参考文献 Reference
稻瘟菌 M. oryzae	MoHat1	D	/	D	I	D	[18]
	MoGcn5	D	/	I	D	D	[19]
	MoSas3	D	Y	D	/	D	[20]
禾谷镰刀菌 F. graminearum	FgHat1	N	N	N	N	N	[24]
	FgHat2	D	/	D	D	D	[25]
	FgGcn5	D	Y	D	D	D	[26-27]
	FgRtt109	D	Y	D	D	D	[26-27]
	FgSas2	D	Y	D	N	N	[26-27]
	FgSas3	D	Y	D	D	D	[26-27]
	FgElp3	D	Y	I	/	D	[27]
	FgHpa2	D	N	N	/	N	[27]
链格孢 A. alternata	AaSas2	N	N	N	N	N	[28]
	AaSas3	D	N	D	D	D	[28]
	AaGcn5	D	Y	D	D	D	[28]
	AaRtt109	D	N	D	D	D	[28]
	AaElp3	D	D	D	D	D	[28]
	AaEsa1	N	N	N	N	/	[28]
	AaNat3	D	Y	D	D	D	[28]
灰葡萄孢B. cinerea	BcSas2	D	/	D	D	D	[30]
果生炭疽菌C. fructicola	CfGcn5	D	Y	D	/	D	[31]
尖孢镰刀菌F. oxysporum	FocGcn5	D	/	D	/	D	[33]
玉米黑粉病菌U. maydis	UmGcn5	D	Y	/	D	D	[34]
大豆疫霉P. sojae	PsGcn5	N	/	/	D	D	[35]