硫丹的生物学效应研究进展

生物技术通报 ›› 2013, Vol. 0 ›› Issue (5): 45-51.

硫丹的生物学效应研究进展

徐丹, 李帅, 张敏, 孙野青

(大连海事大学环境系统生物学研究所，大连 116026)

收稿日期:2012-11-28 修回日期:2013-05-24 出版日期:2013-05-24 发布日期:2013-05-24
作者简介: 徐丹，女，博士，副教授，硕士生导师，研究方向：细胞分子生物学，药理学及小分子RNA；E-mail：jotan1995@163.com
基金资助:
国家自然科学基金项目(21207012)，中央高校基本科研业务费专项资金(2012QN058)

Research Progress on Biological Effect of Endosulfan

Xu Dan, Li Shuai, Zhang Min, Sun Yeqing

(Institute of Environmental Systems Biology，Dalian Maritime University，Dalian 116026)

Received:2012-11-28 Revised:2013-05-24 Published:2013-05-24 Online:2013-05-24
About author:孙野青，女，博士，教授，博士生导师，研究方向：环境系统生物学，空间生物学； E-mail：yqsun@dlmu.edu.cn

摘要/Abstract

摘要： 硫丹是一类持久性有机污染物，与人类许多疾病的发生密切相关而引起人们的广泛关注。虽然硫丹在2011年被列入斯德哥尔摩公约禁用物质列表，但由于其环境行为的特性包括持久性、生物富集性、高生物毒性，具有潜在的致癌致突变性和内分泌干扰素作用，会对环境和人类健康产生长久的影响因而不容忽视。总结近年来有关硫丹的环境行为、生物毒性和对人类的危害，着重对硫丹的细胞毒性进行了归纳、整理和深入的分析，并对未来的研究方向提出有价值的建议。以期能够有利于人们认识其被禁用的原因，并为揭示包括硫丹在内的持久性有机污染物的生物学效应机制提供新的思路。

关键词: 硫丹, 持久性有机污染物, 生物毒性, 致癌性, 致突变, 内分泌干扰素

Abstract: Endosulfan is a class of persistent organic pollutants (POPs), implicated in a variety of human diseases with widespread concern. Endosulfan has been added to Annex A of the Stockholm Convention in 2011, but the impact of endosulfan on the environment and human health still should not be ignored by people. Endosulfan might affect environment and human health for a long time due to its characteristics of the environmental behavior including persistence, bioconcentration and high biological toxicity, as well as potential carcinogenicity, mutagenicity and endocrine disruptor effects. Here, we summarize the recent research overviews on environmental behavior, biological toxicity and harm to human. Especially, we focus on cytotoxicity of endosulfan to collect, sort out and perform further analysis, followed by valuable suggestion about future direction of research work. Hopefully, this review will be helpful to understand the reason that endosulfan is disabled nowadays and provide new idea of revealing the mechanism in biological effects of POPs including endosulfan.

Key words: Endosulfan, Persistent organic pollutants, Biological toxicity, Carcinogenicity, Mutagenicity, Endocrine disruptor

徐丹, 李帅, 张敏, 孙野青. 硫丹的生物学效应研究进展[J]. 生物技术通报, 2013, 0(5): 45-51.

Xu Dan, Li Shuai, Zhang Min, Sun Yeqing. Research Progress on Biological Effect of Endosulfan[J]. Biotechnology Bulletin, 2013, 0(5): 45-51.

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