Nrf2及其相关抗氧化基因的miRNA调控研究进展

生物技术通报 ›› 2013, Vol. 0 ›› Issue (9): 34-37.

Nrf2及其相关抗氧化基因的miRNA调控研究进展

覃玉娥, 刘朝奇

三峡大学分子生物学研究所，宜昌 443002

收稿日期:2013-03-07 修回日期:2013-09-05 出版日期:2013-09-05 发布日期:2013-09-06
作者简介:覃玉娥，女，硕士，研究方向：分子生物学与免疫学；E-mail：1050472287@qq.com

Progress of miRNA Regulation for Nrf2 and Related Antioxidant Genes

Qin Yu’e Liu Chaoqi

Institute of Molecular Biology，Three Gorges University，Yichang 443002

Received:2013-03-07 Revised:2013-09-05 Published:2013-09-05 Online:2013-09-06

摘要/Abstract

摘要： Nrf2在机体抗氧化、维护机体正常生理功能具有重要作用。MicroRNAs（miRNAs）是真核生物中调控基因表达的一类内源性非编码RNA，其大小长约20-25个核苷酸。围绕机体抗氧化相关基因调控的miRNA最新研究进展作一综述。

覃玉娥, 刘朝奇. Nrf2及其相关抗氧化基因的miRNA调控研究进展[J]. 生物技术通报, 2013, 0(9): 34-37.

Qin Yu’e Liu Chaoqi. Progress of miRNA Regulation for Nrf2 and Related Antioxidant Genes[J]. Biotechnology Bulletin, 2013, 0(9): 34-37.

[1]Sangokoya C, Telen MJ, Chi JT. MicroRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease[J]. Blood, 2010, 116：4338-4348.
[2]Bartuma H, Panagopoulos I, Collin A, et al. Expression levels of HMGA2 in adipocytic tumors correlate with morphologic and cytog-enetic subgroups[J]. Molecular Cancer, 2009, 8：36 1186-1476.
[3]Nguyen T, Nioi P, Pickett CB. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress[J].The Journal of Biological Chemistry, 2009, 284：13291-13295.
[4]Singh B, Ronghe AM, Chatterjee A, Bhat NK. MicroRNA-93 regula-tes NRF2 expression and is associated with breast carcinogene-sis[J].Carcinogenesis, 2013, 285（17）：13045-13056.
[5]Yang M, Yao Y, Eades G, et al. MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism[J].Brest Caner Res Treat, 2011, 129（3）：983-991.
[6]Luo Y, Eggler AL, Liu D, et al. Sites of alkylation of human Keap1 by natural chemoprevention agents[J]. J Am Soc Mass Spectrom, 2007, 18：2226-2232.
[7]Li H, Ren YZ, Duan HJ, et al . Effects of tBHQ on the oxidative stress and the expression of Nrf2 in kidney of diabetic mice[J]. Chin Pharmacol Bull, 2009, 25（2）：1341-1344.
[8]Niture SK, Kaspar JW, Shen J, Jaiswal AK. Nrf2 signaling and cell survival[J]. Toxicol Appl Pharmacol, 2010, 244（1）：37-42.
[9]Shin DH, Park HM, Jung KA, et al. The Nrf2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis[J]. Free Radic Biol Med, 2010, 48（8）：1051-1063.
[10]Eades G, Yang M, Yao Y, et al. MiR-200aregulatesNrf2activation by targetingKeap1mRNA in breast cancer cells[J]. Biol Chem, 2011, 286（47）：40725-40733.
[11]van Jaarsveld MT, Helleman J, Boersma AW, et al. MiR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells[J]. Oncogene, 2012, 285（17）：13045-13056.
[12]Li H, Ren YZ, Duan HJ, et al. Effects of tBHQ on the oxidative stress and expression of Nrf2 in kidneys of diabetic mice[J]. Chin Pharmacol Bull, 2009, 25（2）：1341-1344.
[13]Stachurska A, Ciesla M, Kozakowska M, et al. Cross-talk between microRNAs, nuclear factor E2-related factor 2, and heme oxygena-se-1 in ochratoxin A-induced toxic effects in renal proximal tubular epithelial cells[J]. Mol Nutr Food Res, 2013, 57（3）：504-515.
[14]Pulkkinen KH, Yla-Herttuala S, Levonen AL. Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells[J]. Free Radic Biol Med, 2011, 51（11）：2124-2131.
[15]Bates DJ, Li N, Liang R, et al. MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging[J]. Aging Cell, 2010, 9（1）：1-18.
[16]Lee J, Padhye A, Sharma A, et al. A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic Sirtuin 1 levels via microRNA-34a inhibition[J]. J Biol Chem, 2010, 285（17）：12604-12611.
[17]Li N, Muthusamy S, Liang R, et al. Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of MGST1 and Sirt1.[J].Mech Ageing Dev, 2011, 132（3）：75-85.
[18]Okazaki M, Iwasaki Y, Nishiyama M, et al. Terada PPARbeta/delta regulates the human SIRT1 gene transcription vis Sp1[J]. Endocr J, 2010, 57（5）：403-413.
[19]Hasegawa K, Wakino S, Yoshioka K, et al. Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function[J]. J Biol Chem, 2010, 285（17）：13045-13056.