Research Progress on miR-155, EMT and Tumour Invasion/Metastasis

Abstract

Abstract: EMT(epithelial-mesenchymal transition)is one of the key steps for tumor cells to obtain their ability of invasion and metastasis. miR-155 is an important regulator for EMT and effects EMT by targeting the key proteins involved in this process and inhibiting their expression. The function of miR-155 is tissue-and cell-specific, which can promote or inhibit tumor invasion/metastasis in different tumor tissues and cell types depending on the biological characteristics of the targeted protein moleculars. It reviewed the relationship among miR-155, EMT and tumor invasion/metastasis.

Key words: miR-155, EMT, Tumour, Invasion, Metastasis

Wu Liting, Cui Lei, Wang Yanlin, Huang Liming. Research Progress on miR-155, EMT and Tumour Invasion/Metastasis[J]. Biotechnology Bulletin, 2014, 0(3): 55-59.

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