Biotechnology Bulletin ›› 2014, Vol. 0 ›› Issue (8): 46-51.

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Research of 3C Protease Picornaviruses and Its Cleavage Substrates

Liu Yan1,2, Li Bingqing1, Meng Hong1   

  1. 1. Department of Microbiology, Institue of Basical Medicine, Shangdong Academy of Medical Sciences, Ji'nan 250000;
    2. School of Medicine and Life Sciences, Shangdong Academy of Medical Sciences and Ji'an University, Ji'nan 250022
  • Revised:2014-01-28 Online:2014-08-15 Published:2014-08-01
  • Contact: 通讯作者: 孟红,女,教授,研究方向:病原生物学;E-mail:menglc@163.com
  • Supported by:

    国家自然科学基金项目(81000720)

Abstract:

Picornavirus is a big family of animal viruses, viral protein synthesis needs its own proteases’ cleavage to form sructural and functional proteins. 3C protease is one of picornaviruses’ own proteases. 3C can also cleave some host proteins to benifit viral replication. 3C protease’s structural characteristics, active center, cleavage sites and cleavage substrates’ functions are key of further understanding 3C protease mechanism. Here follows the review on these issues.

Key words: Picornavirus, 3C protease, Cleavage substrates