Growth Influence of Allicin and Its Prodrug on Esophageal  Cancer Cells

doi:10.13560/j.cnki.biotech.bull.1985.2015.02.034

Abstract

Abstract: We observed the cancer cell morphology, determined lactate dehydrogenase（LDH） activity and DNA degradation after allicin and its prodrug（alliin + alliinase） treated human esophageal cancer Eca9706 cells. The results showed that the cancer cells became more circular and smaller, the number of living cells decreased, the non-adherent cells and cell debris increased. DNA-Ladder revealed to exist DNA ladder line, which indicated DNA molecule degraded. Cancer cells’ LDH activity treated with allicin and its prodrug was significantly higher than the control group. LDH activity had a time and dose dependent manner with treated concentration increased and time extended. Eca9706 cells’ LDH activity by the prodrug treated was higher than allicin, this confirmed prodrug could cause great damage on cell membrane.

Key words: allicin, allicin prodrug, human esophageal cancer, cell morphology, DNA degradation

Yang Jinbu, Chang Quan'e, Gou Ping, Wei Hongyan. Growth Influence of Allicin and Its Prodrug on Esophageal Cancer Cells[J]. Biotechnology Bulletin, 2015, 31(2): 228-232.

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Growth Influence of Allicin and Its Prodrug on Esophageal Cancer Cells

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