Research Progress on the Biosynthetic and Regulatory Mechanisms of Natamycin in Streptomyces natalensis

doi:10.13560/j.cnki.biotech.bull.1985.2016.05.004

Abstract

Abstract: Natamycin，a polyene-macrolide antibiotic，is a secondary metabolite produced by Streptomyces natalensis. It can not only effectively inhibit the growth of fungi，but also depress the generation of aflatoxin. Thus，it is widely used in the fields such as food preservatives，remedial reagent of fungal keratitis，etc. Skeleton ring of natamycin is firstly synthesized by the catalyst of acetic acid-activated polyketone synthase，and then modified by some other correlated synthases，involving the regulation and expression mechanisms of natamycin biosynthesis-related genes（i.e.，transcriptional regulator’s regulation，pathway-specific regulation，global regulation，and cross-talk regulation，as well as ROS regulation，etc）. A matured molecule of natamycin can be exported out of cells through intracellular transporters. Finally，perspective in the future has been proposed based on the research progress of latest reports.

Key words: natamycin, Streptoyces natalensis, polyketone synthase（PKS）, transcriptional regulators

LU Shi-yao,SUN Li-jie,YUAN Li-xia,ZHU Wei-wei,YAO Jian-ming. Research Progress on the Biosynthetic and Regulatory Mechanisms of Natamycin in Streptomyces natalensis[J]. Biotechnology Bulletin, 2016, 32(5): 26-33.

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