Progress of Immunocyte in the Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue

doi:10.13560/j.cnki.biotech.bull.1985.2019-0542

Abstract

Abstract: Obesity has become a global prevalent disease that threats human health. Brown adipose tissue（BAT）and beige adipocytes have attracted considerable attention as a novel therapeutic intervention in the treatment of obesity,due to the features of increasing energy consumption via thermogenesis. M2 macrophages（alternatively activated macrophages,M2 type）was recently found to have an unexpected involvement in promoting the thermogenic activity of BAT and browning of white adipose tissue（WAT）,i.e.,the processing of beige adipocyte biogenesis,but later researches had come to the opposite conclusion. Whether M2 macrophages involved in browning of WAT is still controversial. Herein,we review the promoting effect of M2 macrophages,type II innate lymphoid cells and eosinophils on BAT thermogenesis and browning of WAT. Also we summarize the studies about the M2 macrophages having no effect and inhibiting effect on browning of white adipose tissue.

Key words: M2 macrophages, type II innate lymphoid cells, eosinophils, brown and brite adipocytes, browning of white adipose tissue

SUN Wen-yang, LIN Jian-chun, GUN Shuang-bao, WANG Jin-yong. Progress of Immunocyte in the Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue[J]. Biotechnology Bulletin, 2020, 36(1): 175-181.

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