Research Progress on Proteins of PEDV Antagonizing Host Innate Immune Responses

doi:10.13560/j.cnki.biotech.bull.1985.2020-0436

Abstract

Abstract:

Porcine epidemic diarrhea virus is one of major causative agents of diarrhea in pigs that causes vomiting,watery diarrhea,and severe dehydration in swine,and with topped 100% mortality in neonatal piglets,leading to enormous economic losses within the swine industry worldwide. The encoded 21 proteins of PEDV are not only involved in virus life cycle,but also play critical role in antagonizing host innate immune responses. Presently,ten viral proteins have been confirmed to have abilities in inhibition interferon responses,i.e.,host immune system was escaped through different mechanisms. In order to deeply understand the functions of these proteins in viral infection and mechanisms in regulation host immune responses,the recent progress on the PEDV proteins involved in host immune regulation has been reviewed,aiming to provide theoretical basis for PEDV vaccine development and disease control.

Key words: porcine epidemic diarrhea virus, innate immune, viral proteins, immunosuppression

CHENG Wen-yu, BAI Yun, JIA Huai-jie, QIANG Tao-yan, ZHAO Hong-yuan, ZHANG Bo-yi, GUO Xiao-hui. Research Progress on Proteins of PEDV Antagonizing Host Innate Immune Responses[J]. Biotechnology Bulletin, 2020, 36(12): 229-238.

Figures/Tables 1

References 52

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