Biotechnology Bulletin ›› 2023, Vol. 39 ›› Issue (6): 109-118.doi: 10.13560/j.cnki.biotech.bull.1985.2022-1027

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Research Advances in the Treatment of Inflammation Bowel Disease Using Escherichia coli Nissle 1917

CHEN Cai-ping1,2,3(), REN Hao1,2,3, LONG Teng-fei1,2,3, HE Bing1,2,3, LU Zhao-xiang1,2,3, SUN Jian1,2,3()   

  1. 1. Department of Veterinary Medicine, South China Agriculture University, Guangzhou, 510000
    2. National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510000
    3. Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510000
  • Received:2022-08-23 Online:2023-06-26 Published:2023-07-07
  • Contact: SUN Jian E-mail:2532129689@qq.com;jiansun@scau.edu.cn

Abstract:

Inflammatory bowel disease(IBD)is a general term of a group of specific intestinal diseases, mainly manifested as chronic and recurrent intestinal inflammation. The burden of IBD has been a global health concern since its incidence and prevalence are elevating rapidly, which has seriously affected people's life and health quality. Over the past decades, tremendous studies underlined the association between incidence of IBD with imbalance of intestinal flora. Therefore, the treatment strategy based on probiotics has become the focus, among of them Escherichia coli Nissle 1917(EcN)has received accumulative attentions. In the current work, we focused on the application and mechanisms of EcN in the treatment of IBD, systematically reviewed the probiotic properties of EcN and its application for treating IBD through regulating epithelial integrity, immune-modulation, mucus protection and gut microbiota homeostasis. Furthermore, the future perspectives on formulating novel therapies based on engineered EcN were discussed, highlighting the applicable and feasible strategies of EcN in IBD curing and prevention. Besides, the prospects for further research in this field were given, providing ideas and references for further in-depth research on the EcN treatment of IBD.

Key words: inflammatory bowel disease, Escherichia coli Nissle 1917, therapeutic effect