Japanese Encephalitis and Its Vaccines

Abstract

Abstract: Japanese encephalitis, an insect-borne zoonotic infectious disease, is caused by Japanese encephalitis virus(JEV)and themost important hosts of which in nature is birds and pigs. This disease occurs mainly in Asia and Central-West Pacific regions, and has becomeone of the most serious encephalitis diseases which threats to human health and affects the development of animal husbandry particular in pigfarming industry. Published date from WHO showed that an estimated 50 000 cases occur in this region, resulting in at least 10 000 deaths and15 000 cases of neuropsychiatric sequelae. However, there is no effective antiviral therapeutic is available to treat JE, and vaccination is the mosteffective method to prevent JEV infection. This paper introduces the epidemiological characteristics and enphalitis disease, focuses on reviewof JE vaccines in the market and the latest research process. The present paper would provide useful reference for use and development of JEvaccines in China.

Key words: Japanese encephalitis , Vaccine IC51 , IMOJEV , SA14-14-2

Shen QiangShi Zixue, Wei Jianchao, Ma Zhiyong. Japanese Encephalitis and Its Vaccines[J]. Biotechnology Bulletin, 2013, 0(1): 56-62.

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