Research Advance in the Resistome in the Microbiome of Livestock Animals

doi:10.13560/j.cnki.biotech.bull.1985.2020-1195

Abstract

Abstract:

Most antibiotics are currently used in livestock production which provides humans with food such as meat,milk,and eggs;consequently,resistances to antibiotics cause a huge threat to the public health in the world. In order to limit the spread of antibiotic resistance from livestock production to humans,it is essential to understand which specific resistance genes are carried by the microbiota in gastrointestinal tract of livestock animals or products. Resistome refers to the collection of all identified antibiotic resistance genes in any given environmental microbiota,and resistome analysis becomes a hot topic in the research field of livestock production. First,we highlight the most recent advances in the resistome analysis and its affecting factors based on sequencing technique in the microbiota of gastrointestinal tract of livestock（piglet,chicken,and ruminant）,as well as in the milk microbiota. We also suggest future research directions,including the standardization of resistome analysis pipeline,research on the expression of resistome using metatranscriptomics technique,and the resistance genes carried by mobile genetic elements. This review aims to light on the regulation of antibiotic resistance genes in livestock production.

Key words: antibiotic, resistome, antibiotic resistance gene, metagenomic, livestock

MA Tao, LU Wei, LI Song-li, FAN Xia. Research Advance in the Resistome in the Microbiome of Livestock Animals[J]. Biotechnology Bulletin, 2021, 37(1): 113-122.

Figures/Tables 2

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