表型组学：解析基因型-表型关系的科学

摘要/Abstract

摘要： 表型组学是近年来发展起来的一门新科学，主要对在不同环境下的基因型全部细胞表型进行系统研究。表型组学在基因型-表型作图、复杂性状疾病的遗传基础研究、作物改良方面都有广泛的应用，同时表型组学研究也面临着巨大挑战。基因组数据的广泛特征直接催生了以基因组序列为研究起点的新科学。就表型组学的学科范畴进行深入浅出的介绍，综述表型组学在基因型-表型作图、复杂性状疾病的遗传基础研究、作物改良方面的应用以及表型组学研究面临的挑战。并就目前生物信息学在表型组学中的应用以及表型组学未来和展望进行讨论。

关键词: 基因型, 表型, 高通量分析平台, 表型组学

Abstract: Phenomics is a new branch of science developed in recent years, which mainly study the cell phenotypes in different environments at systems level. Phenomics is widely used in the genotype-phenotype mapping, the genetic basis research of complex trait diseases, crop genetic improvement. Meanwhile, phenomics research faces huge challenges. Extensive features of genomic data directly spawned a new scientific research based on the genome sequences. This paper introduces the scope of phenomics in simple terms. It summarizes the application of phenomics in the genotype-phenotype mapping, the genetic basis research of complex trait diseases, crop genetic improvement, and the challenges of phenomics research. Meanwhile, it discusses the application of bioinformatics in phenomics, and the future and perspective of phenomics.

Key words: Genotype, Phenotype, High-throughput analysis platform, Phenomics

李宏,韦晓兰. 表型组学：解析基因型-表型关系的科学[J]. 生物技术通报, 2013, 0(7): 41-47.

Li Hong, Wei Xiaolan. Phenomics: A Science of Unravelling the Genotype-Phenotype Relationship[J]. Biotechnology Bulletin, 2013, 0(7): 41-47.

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