全肿瘤细胞抗原研究进展

生物技术通报 ›› 2013, Vol. 0 ›› Issue (8): 23-27.

全肿瘤细胞抗原研究进展

方丽, 胡巍

（山东理工大学生命科学学院，淄博 255049）

收稿日期:2013-03-21 修回日期:2013-08-11 出版日期:2013-08-11 发布日期:2013-09-02
作者简介:方丽，女，硕士研究生，研究方向：细胞分子生物学；E-mail：aiyutiandeliki@163.com

Processing in Whole Tumor Cells Antigens for Cancer Immunotherapy

Fang Li, Hu Wei

(School of Life Sciences, Shandong University of Technology, Zibo 255049）

Received:2013-03-21 Revised:2013-08-11 Published:2013-08-11 Online:2013-09-02

摘要/Abstract

摘要： 全肿瘤细胞抗原在肿瘤预防和免疫治疗上具有潜在的应用前景，其能突破肿瘤单一抗原的局限性，并能诱导激活细胞毒性T淋巴细胞和CD4⁺T辅助细胞。对全肿瘤细胞抗原的种类、负载全肿瘤细胞抗原的DC细胞、全肿瘤细胞抗原修饰与免疫增强作用等方面的研究进行综述。

关键词: 全肿瘤细胞抗原, 树突细胞, 免疫治疗

Abstract: Whole tumor cell（WTC）as tumor antigens is a very promising alternative in tumor immune protection and immunotherapy, which can theoretically eliminate some important limitations in vaccine development. Whole tumor cells express a whole array of tumor associated antigens（TAAs）, and simultaneously can induce CTLs and CD4⁺ T helper cell activation. In this paper, some recent proceedings and current preparing methods of whole tumor cell antigens were reviewed including some types of WTC antigens, DC cells loaded by WTC antigens, and modification and immune enhancement of WTC antigens.

Key words: Whole tumor cell antigen, Dendritic cell, Immunotherapy

方丽, 胡巍. 全肿瘤细胞抗原研究进展[J]. 生物技术通报, 2013, 0(8): 23-27.

Fang Li, Hu Wei. Processing in Whole Tumor Cells Antigens for Cancer Immunotherapy[J]. Biotechnology Bulletin, 2013, 0(8): 23-27.

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