核糖开关及其在抗菌药物方面的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2017.01.012

生物技术通报 ›› 2017, Vol. 33 ›› Issue (1): 114-119.doi: 10.13560/j.cnki.biotech.bull.1985.2017.01.012

核糖开关及其在抗菌药物方面的研究进展

盛树悦¹，陈悦²，张兴梅²，石玉生³

1. 南方医科大学第一临床医学院，广州 510515；
2. 南方医科大学基础医学院神经生物学教研室，广州 510515；
3. 南方医院放疗科，广州 510515

收稿日期:2016-10-14 出版日期:2017-01-25 发布日期:2017-01-19
作者简介:盛树悦，女，临床八年制学生，研究方向：适配子;E-mail：799147901@qq.com
基金资助:
国家自然科学基金项目（81272509,81471388）,南方医院院长基金项目（2015Z007）,广东省自然科学基金项目（2014A0303; 13351）

Research Progresses on Riboswitches and Their Applications in Antimicrobials

SHENG Shu-yue¹, CHEN Yue², ZHANG Xing-mei², SHI Yu-sheng³

1. The First Affiliated Hospital,Southern Medical University,Guangzhou 510515;
2. Department of Neurobiology,School of Basic Medical Science,Southern Medical University,Guangzhou 510515;
3. Department of Radiation Oncology,Nanfang Hospital,Southern Medical University,Guangzhou 510515

Received:2016-10-14 Published:2017-01-25 Online:2017-01-19

摘要/Abstract

摘要： 核糖开关是一类与核酸、氨基酸、金属离子、糖类衍生物以及辅酶等特异性配体结合的RNA元件，它与配体结合后通过调控相应下游的基因表达起到控制细胞生命及活动的作用。目前核糖开关是基因调控方面的研究热点，应用于大量筛选工程菌株、构建新型生物传感器以及作为抗菌药作用的新靶点。综述了几种主要的核糖开关（如：嘌呤核糖开关、赖氨酸核糖开关、环二鸟苷酸核糖开关、glmS核糖开关、TPP核糖开关、FMN核糖开关等）在抗菌药物靶点方面的研究进展。

关键词: 核糖开关, 抗菌药, 新靶点

Abstract: Riboswitch is a class of RNA elements that regulate expressions of corresponding downstream genes and then control cells’ functions by binding with nucleic acids,amino acids,metal ions,derivatives of carbohydrates and coenzymes. Riboswitch has been a research focus in gene regulation in recent years and has been being used in mass screening bacterial strains,constructing new biosensors and as new target of antimicrobials. In this paper,recent research progresses on several important classes of riboswitches（such as purine riboswitch,lysine riboswitch,c-di-GMP riboswitch,glmS riboswitch,TPP riboswitch,FMN riboswitch,etc.）in targeting of antimicrobials are mainly reviewed.

Key words: riboswitch, antimicrobials, new target

盛树悦，陈悦，张兴梅，石玉生. 核糖开关及其在抗菌药物方面的研究进展[J]. 生物技术通报, 2017, 33(1): 114-119.

SHENG Shu-yue, CHEN Yue, ZHANG Xing-mei, SHI Yu-sheng. Research Progresses on Riboswitches and Their Applications in Antimicrobials[J]. Biotechnology Bulletin, 2017, 33(1): 114-119.

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核糖开关及其在抗菌药物方面的研究进展

Research Progresses on Riboswitches and Their Applications in Antimicrobials

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