基因组稳定性与iPS细胞重编程的分子机制

摘要/Abstract

摘要： iPS细胞的研究成果是近年来生命科学的重大突破，研究者也因此获得2012年诺贝尔生理医学奖的殊荣。对iPS细胞基因组不稳定变异的来源，表观遗传修饰及其与iPS细胞重编程过程的关系等进行分析，总结最新的研究成果，并对iPS细胞的应用前景进行展望。

关键词: 诱导性多能干细胞, 基因组不稳定, 拷贝数变异, 表观遗传修饰, 细胞重编程

Abstract: The research findings in iPS cells are the major breakthrough in life science in recent years, which won the Noble Prize in physiology or medicine in 2012. This paper analyzed the source of genomic instability variation, epigenetic modification and its relationship with the iPS cells reprogramming. It summarized the latest research results in this field, and discussed the application prospects of iPS cells.

Key words: Induced pluripotent stem cells, Genomic instability, Copy number variation, Epigenetic modification, Cells reprogramming

李宏. 基因组稳定性与iPS细胞重编程的分子机制[J]. 生物技术通报, 2013, 0(12): 36-42.

Li Hong. Molecular Mechanism of Genomic Stability and iPS Cells Reprogramming[J]. Biotechnology Bulletin, 2013, 0(12): 36-42.

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