PGF2α诱导的早期反应基因参与黄体退化的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2016.02.001

摘要/Abstract

摘要： 哺乳动物卵巢黄体的存留对母畜生殖活动具有重要的作用。前列腺素F_2α(PGF_2α)是哺乳动物的主要溶黄体因子，通过与其受体结合，激活一系列早期反应基因，进而诱导黄体的功能性(孕酮水平下降)和结构性退化(细胞程序性死亡)。虽然PGF_2α已被广泛应用于动物的同期发情、分娩控制和繁殖障碍治疗等方面，但其溶解黄体的分子机制尚未完全明确。综述了PGF_2α受体及其诱导的早期反应基因参与卵巢黄体退化的研究进展，旨在为进一步研究PGF_2α诱导黄体退化的分子机制提供理论依据。

关键词: PGF_2α, 早期反应基因, 黄体退化

Abstract: The remaining mammalian corpus luteum plays an important role in female reproductive activities.Prostaglandin F2 alpha(PGF2 alpha), as a main luteolytic factor of the corpus luteum, through binding to its receptor, activates series of early response genes and induces luteal functional(a decrease in the level of progesterone)and structural degradation (programmed cell death).Although PGF_2αhas been widely used in the control of animal synchronization, delivery control and reproductive barrier, the molecular mechanism in the luteal regression is not yet clear.In this review, the advanced progress of PGF_2α receptor and its induced early response genes in ovarian luteal regression is summarized, which provides a theoretical basis to study the molecular mechanism of PGF_2α-induced luteal regression.

Key words: PGF_2α, early response gene, luteal regression

茆达干, 郭南南, 邝美倩. PGF_2α诱导的早期反应基因参与黄体退化的研究进展[J]. 生物技术通报, 2016, 32(2): 30-37.

MAO Da-gan, GUO Nan-nan, KUANG Mei-qian. The Research Progress of PGF_2α Induced-Early Response Genes Involved in Luteal Regression[J]. Biotechnology Bulletin, 2016, 32(2): 30-37.

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