骨髓间充质干细胞分化过程中表观遗传调控机制的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2016.07.003

摘要/Abstract

摘要： 骨髓间充质干细胞（bone marrow mesenchymal stem cells,BMMSCs）具有自我更新的能力和多向分化潜能,在体外可被诱导分化成多种细胞类型,在骨及软骨组织修复中具有重要的临床应用价值。为研发有效促进BMMSCs定向分化的药物,将BMMSCs更合理安全地应用于临床,有必要阐明表观遗传在BMMSCs分化过程中的调控机制。由于BMMSCs的异常分化可导致疾病的发生,其分化调控机制一直是研究的热点。表观遗传调控,如DNA甲基化、组蛋白乙酰化、组蛋白甲基化及非编码RNA等,对决定BMMSCs分化方向至关重要。阐明表观遗传在BMMSCs分化过程中的调控机制,将有助于研发有效促进BMMSCs定向分化的药物,更合理安全地将BMMSCs应用于临床。就BMMSCs分化中的主要表观遗传调控机制的最新研究进展做一综述,并进行了总结。

关键词: 骨髓间充质干细胞, 细胞分化, 表观遗传调控

Abstract: Bone Marrow Mesenchymal Stem Cells（BMMSCs）,with the potential of self-renewal and multipotent differentiation,may differentiate to be several types of cells by induction,thus hold critical clinic values for the restoration of destroyed bones and cartilages. In order to investigate a medicine that may efficiently promote the directional differentiation of BMMSCs and thus using BMMSCs in clinic more safely and reasonably,it is necessary to illustrate the epigenetic regulation mechanism in the differentiation process of BMMSCs. Abnormal regulation of BMMSCs differentiation may lead to development of several diseases,thus appropriate control of BMMSCs differentiation mechanism has been the hotspot topic of research. Epigenetic regulation,such as DNA methylation,histone acetylation,histone methylation and noncoding RNA,play critical roles in the regulation of BMMSCs differentiation. This review summarizes the progress on major epigenetic regulation mechanisms involved in BMMSCs differentiation in recent years.

Key words: bone marrow mesenchymal stem cells（BMMSCs）, cell differentiation, epigenetic regulation

王连庆, 翟俏丽, 赵培庆, 李涛. 骨髓间充质干细胞分化过程中表观遗传调控机制的研究进展[J]. 生物技术通报, 2016, 32(7): 21-27.

WANG Lian-qing ZHAI Qiao-li ZHAO Pei-qing LI Tao. Research Progress on Epigenetic Regulation Mechanism in the Differentiation of Bone Marrow Mesenchymal Stem Cell[J]. Biotechnology Bulletin, 2016, 32(7): 21-27.

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