支原体脂蛋白及其变异与宿主互作研究进展

生物技术通报 ›› 2013, Vol. 0 ›› Issue (2): 49-54.

支原体脂蛋白及其变异与宿主互作研究进展

倪博^1，2 白方方¹ 刘茂军¹ 冯志新¹ 熊祺琰¹ 魏建忠² 邵国青¹

（1. 江苏省农业科学院兽医研究所农业部兽用生物制品工程技术重点实验室国家兽用生物制品工程技术研究中心，南京 210014; 2. 安徽农业大学动物科技学院，合肥 230036）

收稿日期:2012-09-03 修回日期:2013-02-27 出版日期:2013-02-26 发布日期:2013-02-27
作者简介:倪博，女，硕士研究生，研究方向：动物疫病防控；E-mail ：nanjingnibo@163.com
基金资助:
国家自然科学基金项目（31100135），江苏省农业自主创新基金［CX（11）4038］

Research Progress on Mycoplasma Lipoprotein and Its Variation Interaction with Host

Ni Bo^1，2 Bai Fangfang¹ Liu Maojun¹ Feng Zhixin¹ Xiong Qiyan¹ Wei Jianzhong² Shao Guoqing¹

（1. Institute of Veterinary Medicine，Jiangsu Academy of Agricultural Sciences，Key Laboratory of Veterinary Biological Engineering and Technology，Ministry of AgricultureNational Center for Engineering Research of Veterinary Bio-products，Nanjing 210014 ；2. College of Animal Science，Anhui Agricultural University，Hefei 230036）

Received:2012-09-03 Revised:2013-02-27 Published:2013-02-26 Online:2013-02-27

摘要/Abstract

摘要： 脂蛋白是支原体的重要结构，在支原体与宿主间的互作中有重要作用，近些年越来越多的报道指出脂蛋白在支原体毒力及致病性中占有重要地位。介绍支原体脂蛋白的特性和功能，黏附作用，致炎性反应和诱导细胞凋亡的作用。进一步阐述脂蛋白在基因家族的调控下通过ON/OFF 开关、大小变异、结构重组、基因水平转移及抗原调节等发生抗原?相位变异的机制，以及脂蛋白变异在支原体致病力方面的影响和重要生物学意义。

关键词: 支原体, 脂蛋白, 抗原变异, 表面多样化

Abstract: Lipoproteins are significant structural of mycoplasma, which play an important role in the interactions with host. In recent years there have been many reports proved that lipoproteins may be importantly contributing in the pathogenesis of mycoplasma. In this article describes the characteristic and function of lipoproteins, the role in adherence, the ability leading to inflammatory response and cell apoptosis. Moreover have a review about phase and antigenic variation under the regulation of gene families through ON/OFF molecular switches, size variation, domain shuffling, horizontal gene transfer, and mycoplasmal antigen modulation. As well as the effect of variation of lipoproteins in virulence and the biological significance of diverse surface of mycoplasma also included.

Key words: Mycoplasma, Lipoproteins, Antigenic variation, Surface diversity

倪博, 白方方, 刘茂军, 冯志新, 熊祺琰, 魏建忠, 邵国青. 支原体脂蛋白及其变异与宿主互作研究进展[J]. 生物技术通报, 2013, 0(2): 49-54.

Ni Bo, Bai Fangfang, Liu Maojun, Feng Zhixin, Xiong Qiyan, Wei Jianzhong, Shao Guoqing. Research Progress on Mycoplasma Lipoprotein and Its Variation Interaction with Host[J]. Biotechnology Bulletin, 2013, 0(2): 49-54.

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