Caspase细胞凋亡通路及其在水生无脊椎动物的研究进展

生物技术通报 ›› 2013, Vol. 0 ›› Issue (9): 54-61.

Caspase细胞凋亡通路及其在水生无脊椎动物的研究进展

和四梅, 张丽莉, 王艺磊, 王国栋

1. 集美大学水产学院，厦门 361021；
2.农业部东海海水健康养殖重点实验室，厦门 361021；
3.集美大学水产生物技术研究所，厦门 361021

收稿日期:2013-03-02 修回日期:2013-09-05 出版日期:2013-09-05 发布日期:2013-09-06
作者简介:和四梅，女，硕士研究生，研究方向：水产动物功能基因和基因组学；E-mail：595886508@qq.com
基金资助:
国家自然科学基金项目（41006105，41176152），福建省科技计划重点项目（2011N0022）

Caspase-apoptosis Signal Transduction Pathway and Its Research Advance in Aquatic Invertebrates

He Simei Zhang Lili Wang Yilei Wang Guodong

1. Fisheries College，Jimei University，Xiamen 361021；
2. Key Laboratory of Healthy Mariculture for the East China Sea，Ministry of Agriculture，Xiamen 361021；
3. Institute of Aquaculture Biotechnology，Jimei University，Xiamen 361021

Received:2013-03-02 Revised:2013-09-05 Published:2013-09-05 Online:2013-09-06

摘要/Abstract

摘要： 半胱天冬氨酸酶（caspase）普遍存在于真核生物，在细胞凋亡中具有重要作用，广泛参与胚胎发育、炎症反应、器官发生、变态过程及自稳态维持等多种生理过程。caspase级联反应将细胞外信号传递到细胞内，水解底物蛋白或激活转录因子发挥作用。目前，细胞凋亡通路在哺乳动物的作用机制已有大量的报道，但对水生无脊椎的研究相对较少。综述caspase细胞凋亡通路及其在水生无脊椎动物的研究进展。

Abstract: Caspases exist in all eukaryotic cells and play important a role in cell apoptosis. They are widely involved in embryonic development, inflammation, organogenesis, metamorphosis, homeostasis and other physiological processes. Caspases transduce signals from outside to the cytoplasm or nucleus by a conserved caspase cascade, hydrolyzing intracellular substrate proteins or activating transcription factors to regulate physiological processes. Currently, most of the knowledge about the mechanisms of the caspase -apoptosis pathway focuses on the mammalian system. So far, basic knowledge of the caspase -apoptosis pathway in aquatic invertebrates is limited. In this article, combined data collected in our laboratory, we reviewed the research advance on caspase-apoptosis pathway in aquatic invertebrates to date.

和四梅, 张丽莉, 王艺磊, 王国栋. Caspase细胞凋亡通路及其在水生无脊椎动物的研究进展[J]. 生物技术通报, 2013, 0(9): 54-61.

He Simei Zhang Lili Wang Yilei Wang Guodong. Caspase-apoptosis Signal Transduction Pathway and Its Research Advance in Aquatic Invertebrates[J]. Biotechnology Bulletin, 2013, 0(9): 54-61.

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