Production and Process Development of Anticancer Drug Epothilone

doi:10.13560/j.cnki.biotech.bull.1985.2019-0126

Abstract

Abstract: Epothilone is a class of macrolide-centered compounds with anticancer activity,and it has a strong inhibitory effect on breast cancer and rectal cancer. Its mechanism of action is very similar to the paclitaxel's,that is,mitosis can be prevented at G2-M phase by inducing tubulin polymer to form superstable state,which can inhibit the proliferation of cancer cells and even induce their death. However,its antitumor activity is 10-1000 times higher than that of paclitaxel. As a secondary metabolite of bacteria,epothilone can be produced by microbial fermentation at a large scale,which makes it not restricted by sources like paclitaxel. In addition,because of its relatively simple molecular structure,there is a bright potential for epothilone to have chemical structural modification. Most importantly,epothilone has also shown high activity against some cancer cells that have developed drug resistance. Therefore,its huge medicinal value and market potential can make it a new type of anti-cancer drug after paclitaxel,thus is has an important application value. This paper reviews the research progress of chemical synthesis,biosynthesis,isolation and extraction of epothilone and how to improve the yield of epothilone,so that new researchers in this field have a general understanding of the recent research situation of epothilone,and it may play a guiding role in their later research ideas.

Key words: epothilone, production increase, heterogenous biosynthesis, anticancer drug

TIAN Lu, XUE Ren-zheng, ZHANG Zhi-min, XUE Chun-xian, SHEN Lan-fang, GONG Guo-li. Production and Process Development of Anticancer Drug Epothilone[J]. Biotechnology Bulletin, 2019, 35(10): 198-204.

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