Advance in the Nucleotide Binding and Oligomerization Domain （NOD）-like Receptors （NLRs）

Abstract

Abstract: The innate immune system is the first line of defense against microorganisms, recent studies identified a new kind of protein, the nucleotide binding and oligomerization domain (NOD)-like receptors (NLRs) which can recognize and respond against pathogens, play an important role in the innate immune of the plant and animal. Activation of NLR proteins results in inflammatory responses mediated either by NF-κB, MAPK or Caspase-1 activation. The paper summarized the NLR family and the inflammatory diseases associated with it. The NLR family in the treatment of inflammatory diseases were also prospected.

Key words: Innate immune, NLRs, NOD1, NOD2, Inflammatory diseases

Li Yiping, Wang Xiao. Advance in the Nucleotide Binding and Oligomerization Domain （NOD）-like Receptors （NLRs）[J]. Biotechnology Bulletin, 2013, 0(7): 36-40.

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