Biotechnology Bulletin ›› 2014, Vol. 0 ›› Issue (2): 181-186.

• Papers • Previous Articles     Next Articles

High Throughput Drug Screening on Protein PAN of Influenza Virus

Zhang Guofang1, Li Zhenzhen1, Yao Weili2,3, Wang Lijun2,4, Zhu Xianming5,   

  1. (1. College of Biology EnginzeeringTianjin University of Science & TechnologyTianjin 300222;2. Tianjin International Joint Academy of Biotechnology & MedicineTianjin 300457;3. College of PharmacyNankai UniversityTianjin 300071;4. College of Life ScienceNankai UniversityTianjin 300071;5. Tianjin International Joint Academy of Biotechnology & Medicine Company LimitedTianjin 300457)
  • Received:2013-07-30 Online:2014-02-27 Published:2014-02-27

Abstract: PAN protein, which is an endonuclease and highly conserved in influenza virus, is a potential target for the discovery and development of anti-influenza drugs. Three inhibitors of PAN protein were obtained from a compounds library. The molecular docking analysis showed that these compounds can interact with the divalent metal ions and those amino acid residues in the active sites, implying that these components might be the lead compounds for the novel anti-influenza drugs.