An Investigation of Cellular Autophagy and Oil Accumulation in the Lipomyces starkeyi

doi:10.13560/j.cnki.biotech.bull.1985.2015.02.031

Abstract

Abstract: It was to prove autophagy is involved in the accumulation of lipid in Lipomyces starkeyi. Detecting the expression of autophagy-related gene in different lipid accumulation level to determine whether autophagy is potentially involved in lipid accumulation; promoting autophagy by autophagy accelerator to observe whether there are differences in yeast lipid accumulation level. Results showed that the level of autophagy is low in high lipid accumulation condition compare with low condition. After treatment with autophagy accelerator, the lipid accumulation in yeast is reducing. In Lipomyces starkeyi, autophagy is negatively related to lipid accumulation, the improving of autophagy level will reduce the lipid accumulation in yeast.

Key words: autuphagy, Lipomyces starkeyi, oil accumulation, autophagy ubiquitin-like conjugated system

Han Bing, Yang Qin, Cui Qinghua. An Investigation of Cellular Autophagy and Oil Accumulation in the Lipomyces starkeyi[J]. Biotechnology Bulletin, 2015, 31(2): 208-216.

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