The Research Progress of PGF2α Induced-Early Response Genes Involved in Luteal Regression

doi:10.13560/j.cnki.biotech.bull.1985.2016.02.001

Abstract

Abstract: The remaining mammalian corpus luteum plays an important role in female reproductive activities.Prostaglandin F2 alpha(PGF2 alpha), as a main luteolytic factor of the corpus luteum, through binding to its receptor, activates series of early response genes and induces luteal functional(a decrease in the level of progesterone)and structural degradation (programmed cell death).Although PGF_2αhas been widely used in the control of animal synchronization, delivery control and reproductive barrier, the molecular mechanism in the luteal regression is not yet clear.In this review, the advanced progress of PGF_2α receptor and its induced early response genes in ovarian luteal regression is summarized, which provides a theoretical basis to study the molecular mechanism of PGF_2α-induced luteal regression.

Key words: PGF_2α, early response gene, luteal regression

MAO Da-gan, GUO Nan-nan, KUANG Mei-qian. The Research Progress of PGF_2α Induced-Early Response Genes Involved in Luteal Regression[J]. Biotechnology Bulletin, 2016, 32(2): 30-37.

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The Research Progress of PGF_2α Induced-Early Response Genes Involved in Luteal Regression

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