Casein Kinase 1α in Cell Signalling

Abstract

Abstract: Casein kinase 1α(CK1α)is a member of CK1 family(CK1α, β, γ1, γ2, γ3, δ, ε), which expressed in many eukaryotes ranging from yeast to humans, and the sequence is highly conserved. Mammalian CK1α involved in diverse cellular processes including membrane trafficking, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation etc. In addition, CK1α is needed in the process of Wnt/β-Cat, Hh and NF-κB signalling pathway. The detail functions of CK1α in cell signalling, and provide reference for CK1α research was summarized.

Key words: Casein kinase 1α(CK1α)Wnt/β-Cat, Hh, NF-κB Signalling

Han Guocan, Jiang Shaojie, Zou Feiyan. Casein Kinase 1α in Cell Signalling[J]. Biotechnology Bulletin, 2014, 0(3): 22-29.

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