Research of Hyaluronidases and Future Development

Abstract

Abstract: Hyaluronidase is a kind of glycosidase which mainly degrade hyaluronic acid. Research on hyaluronidase- a negeleted enzyme for a long time increased in recent years. we mainly reviewed the current research on the several resources of hyaluronidase, including human hyaluronidase, bovine testicular hyaluronidase, animal venom hyaluronidase and bacterical hyaluronidase. Moreover, the enzyme activity assays and clinical application were reviewed. Finally the future research on hyaluronidase was prospected.

Key words: Hyaluronidase, Mammal, Venom, Microorganism, Inhibitor

Su Kang, Ji Aiguo. Research of Hyaluronidases and Future Development[J]. Biotechnology Bulletin, 2014, 0(3): 15-21.

References

[1] Reynals FD. Tissue permeability and the spreading factors in infection:A contribution to the host:parasite problem[J]. Bacteriol Rev, 1942, 6(4):197-252.
[2] Stern R, Jedrzejas MJ. Hyaluronidases:their genomics structure, and mechanisms of action[J]. Chemical Reviews, 2006, 106(3):818-839.
[3] Csoka AB, Frost GI, Stern R. The six hyaluronidase-like genes in the human and mouse genomes[J]. Matrix Biology, 2001, 20(8):499-508.
[4] Frost GI, Coska TB, Wong T, et al. Purification, cloning, and expression of human plasma hyaluronidase[J]. Biochemical and Biophysical Research Communications, 1997, 236(1):10-15.
[5] ] Müllegger J, Reitinger S, Lepperdinger G. Hapten-Labeled hyaluronan, a substrate to monitor hyaluronidase activity by enhanced chemiluminescence-assisted detection on filter blots[J]. Analytical Biochemistry, 2001, 293(2):291-293.
[6] Stern R. Hyaluronan catabolism:a new metabolic pathway[J]. European Journal of Cell Biology, 2004, 83(7):317-325.
[7] Miller KA, Shao M, Martin-Deleon PA. Hyalp1 in murine sperm function:evidence for unique and overlapping functions with other reproductive hyaluronidases[J]. Journal of Andrology, 2007, 28:67-76.
[8] Reitinger S, Laschober GT, Fehrer C, et al. Mouse testicular hyaluronidase-like proteins, SPAM1 and Hyall5 but not Hyalp1 degrade hyaluronan[J]. Biochemical Journal, 2007, 401:79-85.
[9] George J, Stern R. Serum hyaluronan and hyaluronidase:very early markers of toxic liver injury[J]. Clinica Chimica Acta, 2004, 348:189-197.
[10] Saitoh H, Takagaki K, Majima M, et al. Enzymatic reconstruction of glycosaminoglycan oligosaccharide chains using the transglycosyla-tion reaction of bovine testicular hyaluronidase[J]. Journal of Biological Chemistry, 1995, 270(8):3741-3747.
[11] Jedrzejas MJ, Stern R. Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysis[J]. Proteins:Strccture, Function, and Bioinformatics, 2005, 61(2):227-238.
[12] Ferrer VP, Mari TL, Germski LH, et al. A Novel hyaluronidase from brown spider(Loxosceles intermedia)venom(Dietrich’s Hyaluronidase):from cloning to functional characterization[J]. PLoS Negl Trop Dis, 2013, 7(5):1-12.
[13] Terwisscha SAC, Armand S, Kalk KH, et al. Stereochemistry of chitin hydrolysis by a plant chitinase/ lysozyme and x-ray structure of a complex with allosamidin evidence for substrate assisted catalysis[J]. Biochemistry, 1995, 34(48):15619-15623.
[14] Gmachl M, Kreil G. Bee venom hyaluronidase is homologous to a membrane protein of mammalian sperm[J]. Proceedings of the National Academy of Sciences of the United States of America, 1993, 90:3569-3573.
[15] Markovic-Housley Z, Miglierini G, Soldatova L, et al. Crystal structure of hyaluronidase, a major allergen of bee venom. [J]. Structure, 2000, 8(10):1025-1035.
[16] Santos LD, Santos KS, Pinto JR, et al. Profiling the proteome of the venom from the social wasp Polybia paulista:a clue to understand the envenoming mechanism[J]. Proteome Res, 2010, 9(8):3867-3877.
[17] Pinto JR, Santos LD, Arcuri HA, et al. Proteomic characterization of the hyaluronidase(E. C. 3. 2. 1. 35)from the venom of social wasp polybia paulista[J]. Protein Pep Lett, 2012, 12(6):624-634.
[18] Ng HC, Ranganathan S, Chua KL, et al. Cloning and molecular characterization of the first aquatic hyaluronidase, SFHYA1, from the venom of stonefish(Synanceja horrida)[J]. Gene, 2005, 346:71-81.
[19] Girish KS, Shashidharamurthy R, Nagaraju S, et al. Isolation and characterization of hyaluronidase a “spreading factor” from Indian cobra(Naja naja)venom[J]. Biochimie, 2004, 86:193-202.
[20] Wahby AF, El-Sayed ME, Mahdy, et al. Egyptian horned viper Cerastes cerastes venom hyaluronidase:Purification, partial characterization and evidence for its action as a spreading factor[J]. Toxicon, 2012, 60(8):1380-1389.
[21] Spellerberg B. Pathogenesis of neonatal streptococcus agalactiae infections[J]. Microbes and Infection, 2000, 2:1733-1742.
[22] Jedrzejas MJ. Pneumococcal virulence factors:structure and function[J]. Microbiology and Molecular Biology Reviews, 2001, 65(2):187-207.
[23] Makris, G, Wright JD, Ingham EI, et al. The hyaluronate lyase of Staphylococcus aureus—a virulence factor?[J]. Microbiology, 2004, 150:2005-2013.
[24] Liu GY, Nizet V. Extracellular virulence factors of group B streptococci[J]. Frontiers in Bioscience, 2004, 9:1794-1802.
[25] Hynes WL, Walton SL. Hyaluronidases of Gram-positive bacteria[J]. FEMS Microbiology Letters, 2000, 183:201-207.
[26] Baker JR, Pritchard DG. Action pattern and substrate specificity of the hyaluronan lyase from group B streptococci[J]. Biochem J, 2000, 348(2):465-471.
[27] El-Saforya NS, Lee GC, Lee CK. Characterization of hyaluronate lyase from streptococcus pyogenes bacteriophage H4489A[J]. Carbohydrate Polymers, 2011, 84:1182-1191.
[28] Mishra P, Akhtar MS, Bhakuni V. Unusual Structural Features of the bacteriophage- associated Hyaluronate Lyase(hylp2)[J]. J Biol Chem, 2006, 281(11):7143-7150.
[29] Lindsay AM, Zhang M, Mitchell Z, et al. The Streptococcus equi prophage-encoded protein SEQ2045 is a hyaluronan-specific hyaluronate lyase that is produced during equine infection[J]. Microbiology, 2009, 155(2):443-449.
[30] Di Ferrante N. Turbidimetric measurement of acid mucopolysacch-arides and hyaluronidase activity[J]. Journal of Biological Chemistry, 1956, 222:303-306.
[31] Asteriou T, Deschrevel B, Delpech B, et al. An improved assay for the N-acetyl -D-glucosamine reducing ends of polysaccharides in the presence of proteins[J]. Analytical Biochemistry, 2001, 293:53-59.
[32] Takahashi T, Ikegami-Kawai M, Okuda, R, et al. A fluorimetric Morgan-Elson assay method for hyaluronidase activity[J]. Analytical Biochemistry, 2003, 322(2):257-263.
[33] Reitinger S, Müllegger J, Lepperdinger G. Xenopus kidney hyaluro-nidase-1(XKH1), a novel type of membrane-bound hyaluronidase solely degrades hyaluronan at neutral pH[J]. FEBS Letters, 2001, 505(2):213-216.
[34] Nakamura T, Majima M, Kubo K, et al. Hyaluronidase assay using fluorogenic hyaluronate as a substrate[J]. Analytical Biochemistry, 1990, 191(1), :21-24.
[35] Calabro A, Benavides M, Tammi M, et al. Microanalysis of enzyme digests of hyaluronan and chondroitin/dermatan sulfate by fluorophore -assisted carbohydrate electrophoresis(FACE)[J]. Glycobiology, 2000, 10(3):273-281.
[36] Krupa JC, Marie Butler A, Mort JS. Quantitative bead assay for hyaluronidase and heparinase I[J]. Analytical Biochemistry, 2003, 319(2):280-286.
[37] Nagata H, Kojima R, Sakurai K, et al. Molecular-weight-based hyaluronidase assay using fluorescent hyaluronic acid as a substrate[J]. Analytical Biochemistry, 2004, 330(2):356-358.
[38] Haas E. On the mechanism of invasion. I. antinvasin I, an enzyme in plasma[J]. J Biol Chem, 1946, 164:63-88.
[39] Khanum SA, Murari SK, Vishwanath BS, et al. Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes[J]. Bioorganic & Medicinal Chemistry Letters, 15:4100-4104.
[40] Salmen S, Hoechstetter J, Kasbauer C, et al. Sulphated oligosaccha-rides as inhibitors of hyaluronidases from bovine testis, bee venom and Streptococcus agalactiae[J]. Planta Medica, 2005, 71:727-732.
[41] Isoyama T, Thwaites D, Selzer MG, et al. Differential selectivity of hyaluronidase inhibitors toward acidic and basic hyaluronidases[J]. Glycobiology, 2006, 16:11-21.
[42] Machiah KD, Girish KS, Gowda TV. A glycoprotein from a folk medicinal plant, Withania somnifera, inhibits hyaluronidase activity of snake venoms[J]. Comp Biochem Physiol C, Toxicol Pharmacol, 2006, 143:158-161.
[43] Sahasrabudhe A, Deodhar M. Anti- hyaluronidsse, Anti- elastase activity of Garcinia indica[J]. International Journal of Botany, 2010, 6(3):299-303.
[44] Piwowarski JP, Kiss AK, Kozlowska-Wojciechowska M. Anti-hyaluronidase and anti-elastase activity screening of tannin-rich plant materials used in traditional Polish medicine for external treatment of diseases with inflammatory background[J]. J Ethnopharmacol, 2011, 137(1):937-941.
[45] Remy M, Pinter F, Nentwich MM, et al. Efficacy and safety of hyaluronidase 75 IU as an adjuvant to mepivacaine for retrobulbar anesthesia in cataract surgery[J]. Cataract Refract Surg, 2008, 34(11):1966-1969.
[46] Hylenex San Diego. CA:Halozyme Therapeutics, Inc, 2008.
[47] LEE A, Grummer SE, Kriegel D, et al. Hyaluronidase[J]. Dermatologic Surgery, 2010, 36:1071-1077.
[48] Hylenex[package insert]. San Diego, CA:Halozyme Therapeutics, Inc. ；2008.
[49] UpToDate. Available at:http://www. uptodate. com. Accessed October 13, 2009.