Biotechnology Bulletin ›› 2015, Vol. 31 ›› Issue (4): 175-183.doi: 10.13560/j.cnki.biotech.bull.1985.2015.03.020

• Review • Previous Articles    

Advances in Production of N-acetyl-D-neuraminic Acid by #br#Whole-cell Biocatalysis 

Zhang Congcong Chen Caixia Chen Xiao Wen Ya Yan Liming Tao Yong   

  1. Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101
  • Received:2014-11-17 Online:2015-04-22 Published:2015-04-22

Abstract: N-acetyl-D-neuraminic acid and its derivatives have versatile biological functions and considerable contribution in the therapeutics field. But the production and wide applications of Neu5Ac are limited by the low yield and high cost. With the development of Molecular Biology and the research of Glycomics, the production Neu5Ac by whole-cell biocatalysis, a novel type of biocatalysis, has attracted researchers’ attention. In this paper, we report that the advances in production of Neu5Ac by whole-cell biocatalysis, and also propose some guidelines for future studies.