Research Progress on Structure and Function of GLP-1R and Screening for Small Molecule Drugs

doi:10.13560/j.cnki.biotech.bull.1985.2017.02.005

Abstract

Abstract: Glucagon-like peptide-1 receptor（GLP-1R）as an important target for type 2 Diabetes mellitus（T2DM）therapy,presents clinic significance. The breakthroughs on GLP-1R structures and functions have been made via structural biology and protein engineering. However,it is still unknown on the analysis of its full length structure,the molecular mechanism of polypeptide binding receptors,and the intrinsic mechanism of receptor activation. Owing to the rapid research progresses relating to GLP-1R,this article briefly describes the structure and function of the GLP-1 receptor and the leading compound of existing small molecule drugs,also discusses the developing direction and application prospects of action mechanism of the GLP-1 receptor molecule structure,aiming to provide structure base for the treatment of T2DM.

Key words: GLP-1R, molecular structure, small molecule drugs

HU Zhong-ping, CHENG Nian, YANG Fan, SU Zheng-ding. Research Progress on Structure and Function of GLP-1R and Screening for Small Molecule Drugs[J]. Biotechnology Bulletin, 2017, 33(2): 30-40.

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