Research Progress on Zinc Finger Protein 6

doi:10.13560/j.cnki.biotech.bull.1985.2018-0449

Abstract

Abstract: Zinc finger,BED-type containing 6（ZBED6）is a novel transcription factor that is closely related to the development of skeletal muscle and it regulates the expression of many genes including insulin-like growth factor 2（IGF2）. It is specific for placental mammals and highly conserved among species according to the available genome sequence data. The binding of ZBED6 gene with the intron 3 of key growth regulation factor IGF2 inhibits the expression of IGF2,which then regulate the cell proliferation and the growth of muscle. This article summarized the current research progress on the physiological function of ZBED6. It has been found that ZBED6 may repress the expression of IGF2 and promote the growth of skeletal muscle,heart,liver and kidney;it can reduce fat deposition,resulting in the changing of the metabolism of large molecules such as protein,lipid,etc.,and plays an important regulatory role in the development of diabetes and cancer. In addition,the article summarized the factors affecting the expression of ZBED6,including base mutations,DNA methylation,histone modifications and palindromic sequence. Finally,the article prospects the practical application potential of ZBED6,for instance,ZBED6,as a transcription factor,is closely related to the growth and development of muscle,knocking ZBED6 out may promote muscle growth,which provides new ideas for the genetic breeding of lean animals.

Key words: ZBED6, insulin-like growth factor 2, growth and development

XIE Wen-ya, ZHANG Chuan-hai, PAN Deng-ke, HE Xiao-yun. Research Progress on Zinc Finger Protein 6[J]. Biotechnology Bulletin, 2018, 34(11): 50-55.

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