Abstract: Electrical signal molecules refer to a class of molecules that have an electrochemical activity as signal-switching role in functional nucleic acids electrochemical biosensors,and can interact with nucleic acids or can be Labeled on nucleic acid strands. Electrical signal molecules are essential part of functional nucleic acids electrochemical biosensors,and crucial for the detection sensitivity and application popularity of functional nucleic acids electrochemical biosensors. In this article we briefly introduced 5 major categories of electrical signal molecules,i.e.,dye class,organometallic complexes,nanomaterials,catalase-like,and organic small molecule. Then we demonstrated their applications in functional nucleic acids electrochemical biosensors,mainly from 3 aspects：the methods of generating electrical signals,practical applications,and the advantages and disadvantages of each electrical signal. In the end,we Look on the future discovery or design of new electrical signal molecules. It’s expected to be useful for the subsequent study of electrical signals.

Key words: electrical signal molecule, functional nucleic acids electrochemical biosensors, signal transition