Biotechnology Bulletin ›› 2013, Vol. 0 ›› Issue (9): 38-42.

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TSC1/ TSC2 Heterodimer and Its Role in Cell Growth Regulation

Qin Yi Wang Yanfeng Wang Zhigang   

  1. College of Life Science,Inner Mongolia University,Hohhot 010021
  • Received:2013-03-20 Revised:2013-09-05 Online:2013-09-05 Published:2013-09-06

Abstract: Tsc1 and Tsc2 as a tumor suppressor gene are widely expressed in human body, which were located at autosome. Their expression products Hamartin/TSC1 and Tuberin/TSC2 directly interact to form heterodimer(TSC1/TSC2)and become active. Tuberous Sclerosis Complex(TSC)occurred because of the mutations of Tsc1 and Tsc2. It is a kind of autosomal dominant multi-system complications with a high penetrance. The incidence of TSC was 1/8 000 and 1/6 000 in adults and children, respectively. TSC1/TSC2 heterodimer can mediate the growth factors, insulin and various environmental stress signals to target the small G protein Rheb GAP(GTPase active protein, GAP)activity and inhibits the activity of mTORC1(mammalian target of rapamycin complex 1). TSC1/TSC2 heterodimer regulates cell growth, migration, differentiation and plays key role in metabolism and embryo development. The genetic characterization of Tsc1 and Tsc2 and the function of their products in cell growth regulation were reviewed.

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