哺乳动物基因组印记的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2015.01.007

生物技术通报 ›› 2015, Vol. 31 ›› Issue (1): 46-50.doi: 10.13560/j.cnki.biotech.bull.1985.2015.01.007

哺乳动物基因组印记的研究进展

陈秀莉^1，2 马利兵

（1.内蒙古科技大学数理与生物工程学院，包头 014010；2.包头师范学院生物科学与技术学院，包头 014030）

收稿日期:2014-07-01 出版日期:2015-01-09 发布日期:2015-01-10
作者简介:陈秀莉，女，硕士，副教授，研究方向：表观遗传学；E-mail：chenxiuli6666@sina.com
基金资助:
国家自然科学基金项目（31160245），内蒙古自治区高等学校青年科技英才支持计划

Research Progress in Genomic Imprinting in Mammals

Chen Xiuli^1，2, Ma Libing

（1. School of Mathematics Physics and Biological Engineering，Inner Mongolia University of Science and Technology，Baotou 014010；2. Faculty of Biological Science and Technical，Baotou Teachers College，Baotou 014030）

Received:2014-07-01 Published:2015-01-09 Online:2015-01-10

摘要/Abstract

摘要： 基因组印记是由亲本来源不同而导致等位基因表达差异的一种遗传现象。基因组印记产生的原因及过程是现代遗传学的一个热点问题。哺乳动物的许多基因组印记特征都使其成为后基因组时代的一个热点生物学问题。进化的基因组印记在哺乳动物生殖、发育中起到了特定的作用。综述了基因组印记的特点、印记基因的印记机理、基因印记与克隆动物的发育、印记基因与疾病的研究进展。

关键词: 基因组印记, 哺乳动物, 克隆动物, 胚胎发育

Abstract: Genomic imprinting is a genetic phenomenon because of the different parents resulted from the allelic gene expression differences. The causes and the process of genomic imprinting is a hot issue of modern genetics. Mammals many genomic imprinting characteristic makes it become a focus biology problems in the post genome era. The evolution of genomic imprinting has played a special role in mammalian reproduction and development. This paper reviewed the characteristics of genomic imprinting、imprinting mechanism of gene imprinting, gene imprinting and the development of cloned animals, the research progress of the imprinting genes and the disease.

Key words: gene imprinting, mammals, cloned animals, embryonic development

陈秀莉,马利兵. 哺乳动物基因组印记的研究进展[J]. 生物技术通报, 2015, 31(1): 46-50.

Chen Xiuli, Ma Libing. Research Progress in Genomic Imprinting in Mammals[J]. Biotechnology Bulletin, 2015, 31(1): 46-50.

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哺乳动物基因组印记的研究进展

Research Progress in Genomic Imprinting in Mammals

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