丁酸梭菌的研究应用进展

生物技术通报 ›› 2013, Vol. 0 ›› Issue (9): 27-33.

丁酸梭菌的研究应用进展

张善亭, 史燕, 张淑丽, 王海宽

天津科技大学生物工程学院工业发酵微生物教育部重点实验室，天津 300457

收稿日期:2013-03-14 修回日期:2013-09-05 出版日期:2013-09-05 发布日期:2013-09-06
作者简介:王海宽，男，教授，硕士生导师，研究方向：酶工程；E-mail：hkwang@tust.edu.cn
基金资助:
张善亭，男，硕士研究生，研究方向：功能微生物；E-mail：zhangshanting2008@163.com

Progress on the Studies and Application of Clostridium butyricum

Zhang Shanting Shi Yan Zhang Shuli Wang Haikuan

Key Laboratory of Industrial Fermentation Microbiology，Ministry of Education，College of Biotechnology，Tianjin University of Science and Technology，Tianjin 300457

Received:2013-03-14 Revised:2013-09-05 Published:2013-09-05 Online:2013-09-06

摘要/Abstract

摘要： 丁酸梭菌是从健康人和动物肠道中分离出的一种厌氧的革兰氏阳性芽孢杆菌，因其能够产生芽孢的益生功能被广泛的研究。丁酸梭菌作为新一代芽孢益生菌制剂，较非芽胞益生菌制剂具有耐热、耐酸和耐多种抗生素等生物学特性，能对宿主产生各种健康作用。如调节肠道微生态平衡、稳定胃肠道功能、产生益生物质、提高机体免疫及促进动物生长等，具有更好的应用发展前景。主要对丁酸梭菌的生物学功能、发酵工艺及其在临床与动物饲料中的应用研究进展进行综述，并展望丁酸梭菌今后的研究方向。

Abstract: Clostridium butyricum, as a probiotic has been studied widely, is a spore-forming, gram-positive anaerobe that is found in intestines of healthy animals and humans. As a novel spore-forming probiotic, C. butyricum can withstand the low pH, heat and many antibiotic compared with non-spore forming probiotics, and exert different health effects in host, such as regulation of intestinal microbial homeostasis, stabilization of the gastrointestinal barrier function, enzymatic activity inducing absorption and nutrition, immunomodulatory effects, improvement of the animal production performance. So it will be used more widely. In this paper, we reviewed advances in the biological function, the fermentation technology and the application in clinic and feed additive of C. butyricum. Some advices were also put forward for further research of C. butyricum.Key words: Clostridium butyricum Probiotic Fermentation Clinic Feed additive

引用本文

张善亭, 史燕, 张淑丽, 王海宽. 丁酸梭菌的研究应用进展[J]. 生物技术通报, 2013, 0(9): 27-33.

Zhang Shanting Shi Yan Zhang Shuli Wang Haikuan. Progress on the Studies and Application of Clostridium butyricum[J]. Biotechnology Bulletin, 2013, 0(9): 27-33.

使用本文

0
/ / 推荐

导出引用管理器 EndNote|Ris|BibTeX

链接本文: https://biotech.aiijournal.com/CN/

https://biotech.aiijournal.com/CN/Y2013/V0/I9/27

参考文献

[1] 李雄彪, 马庆英, 崔云龙. 酪酸梭状芽胞杆菌研究进展[J]. 中国微生态学杂志, 2006, 18（4）：331-335.
[2] 易中华. 饲用微生态制剂丁酸梭菌的研究与应用进展[J]. 饲料研究, 2012（2）：14-17.
[3] 李雄彪, 马庆英, 崔云龙. 酪酸梭菌：肠道健康的卫士[M]. 上海：复旦大学出版社, 2008：37-38.
[4] Woo TDH, Oka K, Takahashi M, et al. Inhibition of the cytotoxic effect of Clostridium difficile in vitro by Clostridium butyricum MIYAIRI 588 strain[J]. Journal of Medical Microbiology, 2011, 60（11）：1617-1625.
[5] 陈秋红, 孙梅, 匡群, 等. 益生菌酪酸菌CB-7的生物学特性研究[J]. 安徽农业科学, 2011, 39（10）：5922-5925.
[6] 李维炯, 微生态制剂的应用研究[M]. 北京：化学工业出版社, 2008.
[7] 张彩云, 刘来亭, 杜灵广, 等. 酪酸芽孢杆菌对断奶仔猪生产性能和血清生化指标的影响[J]. 中国畜牧杂志, 2009（13）：43-45.
[8] Song ZF, Wu LS, Cai LS, et al. Effects of dietary supplementation with Clostridium butyricum on the growth performance and humoral immune response in Miichthys miiuy[J]. Journal of Zhejiang University Science B, 2006, 7（7）：596-602.
[9] Pryde SE, Duncan SH, Hold GL, et al. The microbiology of butyrate formation in the human colon[J]. FEMS Microbiology Letters, 2002, 217（2）：133-139.
[10] Segain J, De La Blétière DR, Bourreille A, et al. Butyrate inhibits inflammatory responses through NFκB inhibition：implications for Crohn's disease[J]. Gut, 2000, 47（3）：397-403.
[11] Gao Q, Qi L, Wu T. Clostridium butyricum activates TLR2-mediated MyD88-independent signaling pathway in HT-29 cells[J]. Molecular and Cellular Biochemistry, 2011, 361（1-2）：31-37.
[12] Hague A, Elder DJE, Hicks DJ, et al. Apoptosis in colorectal tumour cells：induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate[J]. International Journal of Cancer, 1995, 60（3）：400-406.
[13] Ahmad M, Krishnan S, Ramakrishna B, et al. Butyrate and glucose metabolism by colonocytes in experimental colitis in mice[J]. Gut, 2000, 46（4）：493-499.
[14] Shinnoh M, Horinaka M, Yasuda T, et al. Clostridium butyricum MIYAIRI 588 shows antitumor effects by enhancing the release of TRAIL from neutrophils through MMP-8[J]. International Journal of Oncology, 2013, 42（3）：903-911.
[15] Gao QX, Wu TX, Wang JB, et al. Inhibition of bacterial adhesion to HT-29 cells by lipoteichoic acid extracted from Clostridium butyricum[J]. African Journal of Biotechnology, 2011, 10（39）：7633-7639.
[16] Gaenko GP, Khaidukov SV. Inhibition of urokinase synthesis in a tumor cell culture by the lipid fraction from the spores of the anaerobic bacterium Clostridium butyricum[J]. Microbiology, 2010, 79（4）：435-438.
[17] Arimochi H, Morita K, Nakanishi S, et al. Production of apoptosis-inducing substances from soybean protein by Clostridium butyricum：Characterization of their toxic effects on human colon carcinoma cells[J]. Cancer Letters, 2009, 277（2）：190-198.
[18] Purwani EY, Purwadaria T, Suhartono MT. Fermentation RS3 derived from sago and rice starch with Clostridium butyricum BCC B2571 or Eubacterium rectale DSM 17629[J]. Anaerobe, 2012, 18（1）：55-61.
[19] Plangklang P, Reungsang A, Pattra S. Enhanced bio-hydrogen production from sugarcane juice by immobilized Clostridium butyricum on sugarcane bagasse[J]. International Journal of Hydrogen Energy, 2012, 37（20）：15525-15532.
[20] 戚薇, 何玉慧, 李安东, 等. 酪酸梭状芽孢杆菌发酵培养基的优化[J]. 天津科技大学学报, 2010, 25（2）：18-21.
[21] Wang HK, Li AD, Liu FF, et al. Determination of an economical medium for growth of Clostridium butyricum TK2 using orthogonal test[J]. African Journal of Microbiology Research, 2011, 5（14）：1773-1777.
[22] 王海宽, 刘菲菲, 戚薇. 一种丁酸梭菌及丁酸梭菌饲料添加剂的生产方法：中国, ZL201110126498.2[P]. 2011-10-19.
[23] Hakalehto E, Hanninen O. Gaseous CO2 signal initiates growth of butyric-acid-producing Clostridium butyricum in both pure culture and mixed cultures with Lactobacillus brevis[J]. Canadian Journal of Microbiology, 2012, 58（7）：928-931.
[24] Kong Q, He JL, Jia JL, et al. Oral administration of Clostridium butyricum for modulating gastrointestinal microflora in mice[J]. Current Microbiology, 2011, 62（2）：512-517.
[25] 刘丽丽, 李晶, 谢丹, 等. 酪酸梭菌活菌散在防治早产儿喂养不耐受方面的应用[J].中国微生态学杂志, 2011, 23（4）：342-343.
[26] 卓文娟, 罗青明, 陈育红. 四磨汤口服液联合酪酸梭菌活菌散辅助治疗儿童营养不良的临床观察[J]. 中国妇幼保健, 2012, 7：58.
[27] 金巧英, 柳锡永. 酪酸梭菌活菌散剂对新生儿黄疸的影响[J]. 全科医学临床与教育, 2010, 8（2）：205-206.
[28] Imase K, Takahashi M, Tanaka A, et al. Efficacy of Clostridium but-yricum preparation concomitantly with Helicobacter pylori eradica-tion therapy in relation to changes in the intestinal microbiota[J]. Microbiology and Immunology, 2008, 52（3）：156-161.
[29] 姚佳, 陈佳, 汪嵘, 等. 酪酸梭菌活菌胶囊治疗慢性末端回肠炎疗效评价[J]. 中国微生态学杂志, 2011, 12：1104-1106.
[30] Gao Q, Qi T, Wang J. An important role of interleukin-10 in counteracting excessive immune response in HT-29 cells exposed to Clostridium butyricum[J]. BMC Microbiology, 2012, 12（1）：100.
[31] 邹积茹, 常香云, 杨立春. 酪酸梭菌活菌散与制霉菌素片联用治疗婴幼儿鹅口疮的疗效观察[J]. 中国微生态学杂志, 2011, 23（5）：445-446.
[32] 张永红, 王燕, 刘慧婷. 酪酸梭菌双歧杆菌二联活菌治疗儿童反复呼吸道感染临床疗效观察[J]. 中国药物与临床, 2011, 11（10）：1221-1222.
[33] 薛秀丽.酪酸梭菌活菌散在治疗手足口病中的应用[J]. 中国微生态学杂志, 2010, 22（11）：1033-1035.
[34] Gaggìa F, Mattarelli P, Biavati B. Probiotics and prebiotics in animal feeding for safe food production[J]. International Journal of Food Microbiology, 2010, 141：S15-S28.
[35] 孙梅, 陈秋红, 张维娜, 等. 酪酸菌的微胶囊化研究[J]. 畜牧与饲料科学, 2011（4）：13-16.
[36] 刘来亭, 田鹏飞, 杜灵广,等. 酪酸菌对肉鸡生产性能和死淘率及小肠形态结构的影响[J]. 河南农业科学, 2009（7）：130-131.
[37] Zhang B, Yang X, Guo Y, et al. Effects of dietary lipids and Clostri-dium butyricum on the performance and the digestive tract of broiler chickens[J]. Archives of Animal Nutrition, 2011, 65（4）：329-339.
[38] 王润之, 孙彦军, 陈文, 等. 酪酸菌对种鸭生产性能的影响[J]. 河南农业科学, 2009（10）：143-145.
[39] Zhang B, Yang X, Guo Y, et al. Effects of dietary lipids and Clost-ridium butyricum on serum lipids and lipid-related gene expression in broiler chickens[J]. Animal, 2011, 5（12）：1909-1915.
[40] Yang X, Zhang B, Guo P, et al. Effects of dietary lipids and Clostri-dium butyricum on fat deposition and meat quality of broiler chic-kens[J]. Poultry Science, 2010, 89（2）：254-260.

相关文章 0

No related articles found!

编辑推荐

Metrics

阅读次数

全文

摘要

本文评价

摘要

参考文献

相关文章

编辑推荐

Metrics

本文评价

回顶部