小RNA病毒3C蛋白酶及其裂解底物

生物技术通报 ›› 2014, Vol. 0 ›› Issue (8): 46-51.

小RNA病毒3C蛋白酶及其裂解底物

刘艳^1,2, 李冰清¹, 孟红¹

1.山东省医学科学院基础医学研究所微生物学研究室, 济南 250000;
2.济南大学山东省医学科学院医学与生命科学学院, 济南 250022

修回日期:2014-01-28 出版日期:2014-08-15 发布日期:2014-08-01
作者简介:作者简介: 刘艳，女，研究方向：病原生物学；E-mail：lychasedream@163.com

Research of 3C Protease Picornaviruses and Its Cleavage Substrates

Liu Yan^1,2, Li Bingqing¹, Meng Hong¹

1. Department of Microbiology, Institue of Basical Medicine, Shangdong Academy of Medical Sciences, Ji'nan 250000;
2. School of Medicine and Life Sciences, Shangdong Academy of Medical Sciences and Ji'an University, Ji'nan 250022

Revised:2014-01-28 Published:2014-08-15 Online:2014-08-01
Supported by:
国家自然科学基金项目(81000720)

摘要/Abstract

摘要：

小RNA病毒科是一类大的动物病毒科，小RNA病毒蛋白的合成需要自身蛋白酶裂解形成多个结构蛋白和功能蛋白，3C蛋白酶是一些小RNA病毒的自身蛋白水解酶之一，3C蛋白酶还可以裂解一些宿主的蛋白，利于病毒的复制。3C蛋白酶结构特点、活性中心、酶切位点如何，裂解的底物功能怎样，是进一步了解3C蛋白酶作用机制的关键。就这些问题进行综述。

关键词: 小RNA病毒, 3C蛋白酶, 裂解底物

Abstract:

Picornavirus is a big family of animal viruses, viral protein synthesis needs its own proteases’ cleavage to form sructural and functional proteins. 3C protease is one of picornaviruses’ own proteases. 3C can also cleave some host proteins to benifit viral replication. 3C protease’s structural characteristics, active center, cleavage sites and cleavage substrates’ functions are key of further understanding 3C protease mechanism. Here follows the review on these issues.

Key words: Picornavirus, 3C protease, Cleavage substrates

刘艳, 李冰清, 孟红. 小RNA病毒3C蛋白酶及其裂解底物[J]. 生物技术通报, 2014, 0(8): 46-51.

Liu Yan, Li Bingqing, Meng Hong. Research of 3C Protease Picornaviruses and Its Cleavage Substrates[J]. Biotechnology Bulletin, 2014, 0(8): 46-51.

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