生物技术通报 ›› 2014, Vol. 0 ›› Issue (8): 40-45.

• 综述与专论 • 上一篇    下一篇

启动子结构和功能研究进展

王婧, 李冰, 刘翠翠, 朱阵, 张继瑜   

  1. 中国农业科学院兰州畜牧与兽药研究所 农业部兽用药物创制重点实验室, 兰州 730050
  • 修回日期:2013-11-22 出版日期:2014-08-15 发布日期:2014-08-01
  • 作者简介:作者简介: 王婧,女,博士研究生,研究方向:兽医药理学与新药创制;E-mail:kenhtsjj@163.com

Advances of the Studies on Structure and Function of Promoter

Wang Jing, Li Bing, Liu Cuicui, Zhu Zhen, Zhang Jiyu   

  1. Key Laboratory for Veterinary Drug Innovation, Ministry of Agriculture, Lanzhou Institute of Husbandry and Veterinary Pharmaceutical Science, Chinese Academy of Agricultural Sciences, Lanzhou 730050
  • Revised:2013-11-22 Published:2014-08-15 Online:2014-08-01
  • Supported by:

    国家肉牛牦牛产业技术体系建设专项资金(CARS-38)

摘要:

转录起始是一种最重要的表达调节方式,通过多种蛋白质与启动子的配位结合起始转录,参与基因的表达调控过程。而启动子作为基因表达调控的重要顺式作用原件,在原核和真核生物中均存在。对核心启动子结构特征中多种保守顺式调控原件及基本转录因子的结构和功能进行了阐述。

关键词: 启动子, 结构, 顺式作用元件, 功能, 转录因子

Abstract:

Gene expression and its regulation are dependent, on to a great extent, on transciption. An elementary transciption reaction is initiated by the recognition of regulatory regions and especially promoters. Promoters is the cis-regulatory element of gene expression and its regulation, exsit in eukaryotes and prokaryotes. This paper expounded on the general characteristics and the function of promoter segment and cis-element functions.

Key words: Promoter, Structure, cis-acting elements, Function, Transcription factor