肺部菌群与呼吸道疾病的相互关系

doi:10.13560/j.cnki.biotech.bull.1985.2019-0905

摘要/Abstract

摘要： 由于呼吸道黏膜免疫系统具有很好的防御保护作用和强大的清除病原体的能力,过去学术界曾经一度认为健康机体的肺是无菌的。随着不依赖于体外培养的第二代测序技术的发展,关于肺部共生微生物的结构组成及其免疫调节功能的研究越来越受重视。肺部菌群的结构组成与出生方式、饮食结构、生活环境和抗生素使用等多种因素有关,生命早期的肺部菌群的形成和发育会影响全生命周期的呼吸道疾病的发生和发展。肺部菌群通过与宿主免疫系统相互作用调节肺部免疫稳态,还可以与肠道菌群、呼吸道病毒相互作用影响呼吸道感染。因此,干预生命早期肺部菌群的结构组成可以成为预防和控制呼吸道疾病的有效策略和新靶点。

关键词: 肺部菌群, 免疫稳态, 炎症反应, 呼吸道疾病

Abstract: The respiratory tract mucosal immune system has good defensive and protective effects against invaded pathogens and strong eliminating ability,therefore the lungs of healthy organisms are considered sterile for a long time. With the development of the culture-independent sequencing technology,studies on the composition structure and immune regulating functions of lung microbiota are much focused. Early life development and maturation of respiratory microbiota are shaped by birth mode,diet structure,living environment and antibiotic expose,and the formation and development of lung microbiota in early life might affect the occurrence and development of respiratory diseases throughout the life cycle. The interactions among lung microbiota,host immune system,intestinal microbiota and respiratory viruses can regulate the immune homeostasis and inflammatory infection of the lung. Therefore,early life intervention of lung microbiota communities can be explored as an effective strategy and novel target to prevent and control respiratory diseases.

Key words: lung microbiota, immunity homeostasis, inflammatory response, respiratory disease

李宗杰, 狄荻, 李蓓蓓. 肺部菌群与呼吸道疾病的相互关系[J]. 生物技术通报, 2020, 36(2): 188-192.

LI Zong-jie, DI Di, LI Bei-bei. The Relationship Between Lung Microbiota and Respiratory Diseases[J]. Biotechnology Bulletin, 2020, 36(2): 188-192.

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