miR-143生物学功能的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2016-1158

摘要/Abstract

摘要： microRNA 是一类广泛存在于真核生物中长度约为21-25 nt的非编码RNA,通常在转录后水平抑制靶基因的表达。miR-143广泛存在于不同物种中,近年来的研究表明miR-143是一个典型的多功能microRNA。现就miR-143在细胞增殖、分化、凋亡及肿瘤发生等方面的生物学功能进行综述,以期为相关研究提供参考。

关键词: miR-143, 生长发育, 疾病

Abstract: microRNAs are non-coding small RNAs with 21-25 nucleotides that ubiquitously are expressed in the eukaryote,and usually inhibit the expressions of its target genes at the post-transcriptional level. In recent years,miR-143 has been reported as canonical and multifunctional microRNA,which is widely expressed in various species. This paper reviews the biological functions of miR-143 such as cell proliferation,differentiation,apoptosis and tumorigenesis,aiming at providing a reference for relevant research.

Key words: miR-143, growth and development, disease

甘麦邻, 杨露, 谭娅, 杨琼, 蒲红州, 张顺华, 朱砺. miR-143生物学功能的研究进展[J]. 生物技术通报, 2017, 33(6): 16-23.

GAN Mai-lin, YANG Lu, TAN Ya, YANG Qiong, PU Hong-zhou, ZHANG Shun-hua, ZHU Li. Research Progress on miR-143’s Biological Function[J]. Biotechnology Bulletin, 2017, 33(6): 16-23.

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